ArticleNeurochemical research2006
Successful treatment of epilepsy with serotonin reuptake inhibitors: proposed mechanism.
Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
- Sudden unexpected death in epilepsy: Respiratory mechanisms.Handbook of clinical neurology · 2022Review
- Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats.Arquivos de neuro-psiquiatria · 2022Article
- A ketogenic diet protects DBA/1 and Scn1aEpilepsy & behavior : E&B · 2021Article
- Serotonin and sudden unexpected death in epilepsy.Experimental neurology · 2020Review
- A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial).Pilot and feasibility studies · 2019Article
- Model systems for studying cellular mechanisms of SCN1A-related epilepsy.Journal of neurophysiology · 2016Review
- Some cross-talks between immune cells and epilepsy should not be forgotten.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Review
- Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current.Journal of neurophysiology · 2014Article
- Depression in temporal lobe epilepsy: a review of prevalence, clinical features, and management considerations.Epilepsy research and treatment · 2012Article
- Epileptic seizures but not pseudoseizures are associated with decreased density of the serotonin transporter in blood platelet membranes.Neurochemical research · 2008Article
- Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.Brain : a journal of neurology · 2008Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widely used antidepressants Specific Serotonin Reuptake Inhibitors (SSRI) have been tried with success as anticonvulsants in cases of nonsymptomatic epilepsy. This attempt was performed on the basis of experimental data suggesting the involvement of impairments of the serotonin system in the genesis of epilepsy. This overview summarizes the clinical data and presents biochemical and neurochemical evidences suggesting the mechanism of the therapeutic effects of SSRI in nonsymptomatic epilepsy. In particular, studies on blood-borne neutral amino acids and platelet serotonin transporter (SERT) in epileptics suggest: (a) That a decreased brain availability of tryptophan may be related to some types of epilepsy. (b) That reduction of the density of SERT may be a homeostatic reaction in the brain following epileptic seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.