ArticleJournal of molecular histology2006
Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.
Article in Journal of molecular histology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression.Cancer biology & therapy · 2024Article
- An Update on the Role of Ubiquitination in Melanoma Development and Therapies.Journal of clinical medicine · 2021Review
- Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators.Cell reports · 2019Article
- Variation in expression of small ubiquitin-like modifiers in injured sciatic nerve of mice.Neural regeneration research · 2019Article
- Article
- SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians.Cellular and molecular life sciences : CMLS · 2018Article
- Implication of SUMO E3 ligases in nucleotide excision repair.Cytotechnology · 2015Article
- Combined aberrant expression of microRNA-214 and UBC9 is an independent unfavorable prognostic factor for patients with gliomas.Medical oncology (Northwood, London, England) · 2014Article
- Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites.BMC cancer · 2012Article
- SUMOhydro: a novel method for the prediction of sumoylation sites based on hydrophobic properties.PloS one · 2012Article
- Gene expression patterns in the histopathological classification of epithelial ovarian cancer.Experimental and therapeutic medicine · 2010Article
- The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation.Journal of cellular and molecular medicine · 2009Review
- Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis.Nucleic acids research · 2008Article
- Emerging roles of the SUMO pathway in mitosis.Cell division · 2008Article
- SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.Nature cell biology · 2007Article
- RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.Biochemical and biophysical research communications · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
DNA damage repair is an important cell function for genome integrity and its deregulation can lead to genomic instability and development of malignancies. Sumoylation is an increasingly important ubiquitin-like modification of proteins affecting protein stability, enzymatic activity, nucleocytoplasmic trafficking, and protein-protein interactions. In particular, several important DNA repair enzymes are subject to sumoylation, which appears to play a role in copping with DNA damage insults. Recent reports indicate that Ubc9, the single SUMO E2 enzyme catalyzing the conjugation of SUMO to target proteins, is overexpressed in certain tumors, such as lung adenocarcinoma, ovarian carcinoma and melanoma, suggestive of its clinic significance. This review summarizes the most important DNA damage repair pathways which are potentially affected by Ubc9/SUMO and their role in regulating the function of several proteins involved in the DNA damage repair machinery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.