ArticleCurrent genetics2006
Chromosome pairing and meiotic recombination in Neurospora crassa spo11 mutants.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Adaptive Spo11 RNA editing gate optimizes meiosis I pace and mitotic proliferation while preserving ascospore formation.Science advances · 2026Article
- A winged-helix DNA-binding protein is essential for self-fertility during sexual development of the homothallic fungusmSphere · 2024Article
- Dynamic configurations of meiotic DNA-break hotspot determinant proteins.Journal of cell science · 2022Article
- Recombination-independent recognition of DNA homology for meiotic silencing inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Recombination-independent recognition of DNA homology for repeat-induced point mutation.Current genetics · 2017Review
- Article
- Centromere pairing--tethering partner chromosomes in meiosis I.The FEBS journal · 2015Review
- Initiation of meiotic homologous recombination: flexibility, impact of histone modifications, and chromatin remodeling.Cold Spring Harbor perspectives in biology · 2015Review
- Ploidy variation in multinucleate cells changes under stress.Molecular biology of the cell · 2015Article
- Direct recognition of homology between double helices of DNA in Neurospora crassa.Nature communications · 2014Article
- On the role of AtDMC1, AtRAD51 and its paralogs during Arabidopsis meiosis.Frontiers in plant science · 2014Review
- Residual recombination in Neurospora crassa spo11 deletion homozygotes occurs during meiosis.Molecular genetics and genomics : MGG · 2013Article
- Multiple opposing constraints govern chromosome interactions during meiosis.PLoS genetics · 2013Article
- Female meiotic sex chromosome inactivation in chicken.PLoS genetics · 2009Article
- Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.Genome dynamics and stability · 2008Article
- Rapid genetic mapping in Neurospora crassa.Fungal genetics and biology : FG & B · 2007Article
- Meiotic silencing and the epigenetics of sex.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some organisms, such as mammals, green plants and fungi, require double-strand breaks in DNA (DSBs) for synapsis of homologous chromosomes at pachynema. Drosophila melanogaster and Caenorhabditis elegans are exceptions, achieving synapsis independently of DSB. SPO11 is responsible for generating DSBs and perhaps for the initiation of recombination in all organisms. Although it was previously suggested that Neurospora may not require DSBs for synapsis, we report here that mutation of Neurospora spo11 disrupts meiosis, abolishing synapsis of homologous chromosomes during pachynema and resulting in ascospores that are frequently aneuploid and rarely viable. Alignment of homologues is partially restored after exposure of spo11 perithecia to ionising radiation. Crossing over in a spo11 mutant is reduced in two regions of the Neurospora genome as expected, but is unaffected in a third.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.