ArticleInternational journal of colorectal disease2007
Increased detection rate and potential prognostic impact of disseminated tumor cells in patients undergoing endorectal ultrasound for rectal cancer.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Circulating Tumour Cell Release after Cement Augmentation of Vertebral Metastases.Scientific reports · 2017Article
- Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?Nature reviews. Clinical oncology · 2017Review
- Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology.Head & neck · 2016Article
- Prognostic relevance of minimal residual disease in colorectal cancer.World journal of gastroenterology · 2014Review
- Prognostic significance of isolated tumor cells in patients with colorectal cancer in recent 10-year studies.Molecular and clinical oncology · 2013Review
- Does stenting of left-sided colorectal cancer as a "bridge to surgery" adversely affect oncological outcomes? A comparison with non-obstructing elective left-sided colonic resections.International journal of colorectal disease · 2012Article
- Diagnostic endoscopic ultrasonography: assessment of safety and prevention of complications.World journal of gastroenterology · 2012Review
- Preoperative staging of rectal carcinoma by endorectal ultrasound: is there a learning curve?International journal of colorectal disease · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHematogenous tumor-cell dissemination during diagnostic and therapeutic procedures in patients with colorectal cancer has been demonstrated.
objectiveThe aim of this study was to investigate the extent of disseminated tumor cells in blood samples of rectal cancer patients after endorectal ultrasound and to determine its prognostic relevance. MATERIALS AND
methodsPeripheral venous blood samples from 45 patients with rectal cancer were taken before and after endorectal ultrasound. Blood samples were examined using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to amplify cytokeratin 20 transcripts. Overall survival of the patients was calculated by the Kaplan-Meier method.
resultsDisseminated tumor cells were detected in peripheral blood samples of 17 of 45 (38%) patients before and after endorectal ultrasound. Circulating tumor cells were found in 11 of 45 (24%) patients only after endorectal ultrasound (p=0.006). There was a clear trend toward a worse prognosis in patients with tumor cells in blood samples after endorectal ultrasound, but this difference was not statistically significant.
conclusionThis study demonstrates significantly increased hematogenous tumor-cell dissemination after endorectal ultrasound in rectal cancer patients. Patients with tumor cells in blood samples after endorectal ultrasound tend to have a worse prognosis. The potential prognostic impact of this finding is presently unclear and has to be further validated in larger clinical trials.
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