ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Dietary determinants of post-menopausal bone loss at the lumbar spine: a possible beneficial effect of iron.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Dietary magnesium intake, bone mineral density and risk of fracture: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- The Association between Dietary and Circulating Copper Levels and Osteoporosis: a Scoping Review.Biological trace element research · 2026Article
- The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration.Scientific reports · 2025Article
- Iron and Bone Pathophysiology.Advances in experimental medicine and biology · 2025Review
- The Effect of Doping on the Electrical and Dielectric Properties of Hydroxyapatite for Medical Applications: From Powders to Thin Films.Materials (Basel, Switzerland) · 2024Review
- Iron Deficiency and Iron Deficiency Anemia: Potential Risk Factors in Bone Loss.International journal of molecular sciences · 2023Review
- Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy.Frontiers in nutrition · 2023Review
- Ferroptosis: A New Regulatory Mechanism in Osteoporosis.Oxidative medicine and cellular longevity · 2022Review
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- Evidence of Modular Responsiveness of Osteoblast-Like Cells Exposed to Hydroxyapatite-Containing Magnetic Nanostructures.Biology · 2020Article
- 3D Superparamagnetic Scaffolds for Bone Mineralization under Static Magnetic Field Stimulation.Materials (Basel, Switzerland) · 2019Article
- A Precautionary Approach to Guide the Use of Transition Metal-Based Nanotechnology to Prevent Orthopedic Infections.Materials (Basel, Switzerland) · 2019Review
- Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis.PloS one · 2018Article
- Effects of Iron on Physical and Mechanical Properties, and Osteoblast Cell Interaction in β-Tricalcium Phosphate.Annals of biomedical engineering · 2017Article
- Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors.Haematologica · 2016Article
- Copper, iron, and selenium dietary deficiencies negatively impact skeletal integrity: A review.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women.Bone · 2016Article
- Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Observational
- Intrinsically superparamagnetic Fe-hydroxyapatite nanoparticles positively influence osteoblast-like cell behaviour.Journal of nanobiotechnology · 2012Article
- The use of superparamagnetic nanoparticles for prosthetic biofilm prevention.International journal of nanomedicine · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious studies suggesting different effects of diet on post-menopausal bone loss may have given conflicting results because they sometimes failed to exclude confounding conditions or used imprecise methodology.
designTo identify dietary determinants of bone loss from the lumbar spine after menopause in women not taking hormone replacement who developed no evidence of spondylotic or sclerotic degenerative disease, forty-three women were followed with repeated (mean = 12) measurements of bone mineral density (BMD) at L2-4 for 11-14 years. Eleven developed evidence suggestive of degenerative disease and were excluded. Diet was assessed at the beginning of the study and 2.5 years later using 3-day and 7-day periods of weighed intakes. Nutrients estimated were: carbohydrate, fat, protein, fibre, calcium, magnesium, iron, phosphorus, copper, zinc and six vitamins. We tested the ability of diet to predict post-menopausal bone loss using stepwise regression.
resultsEach woman's BMD change was described by a single coefficient after log transformation of the BMD data. The best model for BMD loss including dietary factors alone had two significant determinants: daily energy or protein (p=0.0003) intake was adverse, while dietary iron (p=0.002) was predictive of bone maintenance, an effect that persisted if iron was expressed as a ratio to energy intake. Adding body mass index to the model increased the goodness of fit (R (2)adj rose from 0.33 to 0.42) without affecting the statistical significance of the dietary determinants.
conclusionsDiet may influence bone loss after menopause, with dietary iron (or an associated factor) possibly having a protective effect on bone at the spine.
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