ArticleJournal of molecular neuroscience : MN2006
Bax inhibitor-1 protects neurons from oxygen-glucose deprivation.
Article in Journal of molecular neuroscience : MN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis.Molecular neurobiology · 2025Article
- BAX regulates dendritic spine development via mitochondrial fusion.Neuroscience research · 2022Article
- BAX inhibitor-1: between stress and survival.The FEBS journal · 2020Review
- Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model.Disease models & mechanisms · 2019Article
- Article
- The characteristics of Bax inhibitor-1 and its related diseases.Current molecular medicine · 2014Review
- The protective role of Bax inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A.Scientific reports · 2013Article
- Effects of chronic mild stress in female bax inhibitor-1-gene knockout mice.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2012Article
- Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice.Molecules and cells · 2012Article
- Low levels of Bax inhibitor-1 gene expression increase tunicamycin-induced apoptosis in human neuroblastoma SY5Y cells.Neural regeneration research · 2012Article
- The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.The Journal of biological chemistry · 2012Article
- BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.The EMBO journal · 2011Article
- Article
- Endoplasmic reticulum stress and diabetic retinopathy.Vascular health and risk management · 2008Review
- Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders.Journal of neuroscience research · 2007Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Bax ihibitor-1 (BI-1) has been characterized as an inhibitor of Bax-induced cell death in plants and various mammalian cell systems. To explore the function of BI-1 in neurons, we overexpressed BI-1 tagged to HA or GFP in rat nigral CSM14.1 and human SH-SY5Y neuroblastoma cells. Stable BI-1 expression proved marked protection from cell death induced by thapsigargine, a stress agent blocking the Ca2+-ATPase of the endoplasmic reticulum (ER) but failed to inhibit cell death induced by staurosporine, a kinase inhibitor initiating mitochondria-dependent apoptosis. Moreover, BI-1 was neuroprotective in a paradigm mimicking ischemia, namely oxygen-glucose as well as serum deprivation. Examination of the subcellular distribution revealed that BI-1 predominantly locates to the ER and nuclear envelope but not mitochondria. Taken together, BI-1 overexpression in the ER is protective in neurons, making BI-1 an interesting target for future studies aiming at the inhibition of neuronal cell death during neurodegenerative diseases and stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.