ArticleJournal of clinical microbiology2006
Analysis of the 5' noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in France.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Hepatitis C virus prevalence among men who have sex with men: a cross-sectional study in 12 Brazilian cities.BMC infectious diseases · 2023Article
- Phylogenetic analysis of the 5' untranslated region of HCV from cirrhotic patients in Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2021Article
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- Interrelationship of hepatitis C virus genotypes with patient characteristics in Bahrain.Hepatic medicine : evidence and research · 2017Article
- Correlation Study Between HCV Genotypes Distribution Pattern and Viral Load in a Tertiary Care Hospital in Kolkata, India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Comparison of Abbott RealTime HCV Genotype II with Versant line probe assay 2.0 for hepatitis C virus genotyping.Journal of clinical microbiology · 2015Article
- Current molecular methods for the detection of hepatitis C virus in high risk group population: A systematic review.World journal of virology · 2015Review
- Hepatitis C virus genotyping methods: evaluation of AmpliSens(®) HCV-1/2/3-FRT compared to sequencing method.Journal of clinical laboratory analysis · 2014Article
- Subtyping genotype 2 hepatitis C viruses from Tunisia: identification of two putative new subtypes.Virus genes · 2014Article
- Hepatitis C genotype and associated risks factors of patients at University Kebangsaan Malaysia Medical Centre.Pakistan journal of medical sciences · 2013Article
- Comparative performance evaluation of hepatitis C virus genotyping based on the 5' untranslated region versus partial sequencing of the NS5B region of brazilian patients with chronic hepatitis C.Virology journal · 2011Article
- Distribution of hepatitis c virus (hcv) genotypes in patients with chronic infection from Rondônia, Brazil.Virology journal · 2011Article
- Hepatitis C virus genotyping using an oligonucleotide microarray based on the NS5B sequence.Journal of clinical microbiology · 2010Article
- Anti-HCV reactive volunteer blood donors distribution character and genotypes switch in Xi'an, China.Virology journal · 2010Article
- Correlation of the 5'untranslated region (5'UTR) and non-structural 5B (NS5B) nucleotide sequences in hepatitis C virus subtyping.International journal of molecular epidemiology and genetics · 2010Article
- Development of hepatitis C virus genotyping by real-time PCR based on the NS5B region.PloS one · 2010Article
- Investigation of putative multisubtype hepatitis C virus infections in vivo by heteroduplex mobility analysis of core/envelope subgenomes.Journal of virology · 2008Article
- Complete genome of a European hepatitis C virus subtype 1g isolate: phylogenetic and genetic analyses.Virology journal · 2008Article
- Molecular epidemiology of HCV monoinfection and HIV/HCV coinfection in injection drug users in Liuzhou, Southern China.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 5' noncoding region (5' NCR) of the hepatitis C virus (HCV) has become the standard for genotyping even though several reports show that its use can result in classification errors. The purpose of this study was to perform genotyping based on sequence analysis of the NS5b region in a set of 357 HCV strains isolated from blood donors in France in 2002 and 2003. Results were compared with those previously obtained using 5' NCR analysis, and HCV subtype distribution was reevaluated. Twenty-six of 120 strains (approximately 22%) initially identified as genotype 1b by 5' NCR region sequence analysis were reclassified as genotype 1a by NS5b region sequence analysis. Similarly, 14 of 23 strains (approximately 61%) initially identified as 2a/2c were reclassified as non-2a and non-2c subtypes, and 12 of 22 strains (approximately 45%) initially identified as 4c/4d subtypes were reclassified as non-4c and non-4d subtypes. Sequence analysis of the NS5b region also revealed 5 putative new subtype 2 variants and 2 putative new subtype 4 variants. Although these findings demonstrated full agreement between 5' NCR and NS5b sequence analysis with regard to type classification, genotyping based on phylogenetic analysis of the NS5b region is more accurate for subtype determination than genotyping based on analysis of the 5' NCR. Sequence analysis of the NS5b region is mandatory for epidemiologic studies.
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