ArticleNucleic acids research2006
Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
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- Alternative Splicing of the NF-Y Subunit, NF-YA, in Neuroblastoma Phenotype Heterogeneity.Cancers · 2026Review
- A beneficial adaptive role for CHOP in driving cell fate selection during ER stress.EMBO reports · 2024Article
- HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.ACS chemical biology · 2021Article
- Proteotoxic Stress and Cell Death in Cancer Cells.Cancers · 2020Review
- A gene signal amplifier platform for monitoring the unfolded protein response.Nature chemical biology · 2020Article
- NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin.Nature metabolism · 2020Article
- The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation.Biological psychiatry · 2020Article
- BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.The Journal of cell biology · 2019Article
- Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells.Journal of molecular medicine (Berlin, Germany) · 2019Article
- CONCORD biomarker prediction for novel drug introduction to different cancer types.Oncotarget · 2018Article
- Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS.Scientific reports · 2016Article
- Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences.Frontiers in genetics · 2013Review
- Transcriptional regulation of mouse mesencephalic astrocyte-derived neurotrophic factor in Neuro2a cells.Cellular & molecular biology letters · 2013Article
- Article
- bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy.PloS one · 2013Article
- Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes.The Journal of biological chemistry · 2012Article
- Targeting Huntington's disease through histone deacetylases.Clinical epigenetics · 2011Article
- NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table.Cell death & disease · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Response to stresses that alter the function of the endoplasmic reticulum is an important cellular function, which relies on the activation of specific genes. Several transcription factors (TFs) are known to affect this pathway. Using RT-PCR and ChIP assays, we studied the recruitment of promoter-specific TFs, general TFs and epigenetic marks in activated promoters. H3-K4 di- and tri-methylation and H3-K79 di-methylation are present before induction. H3 acetylation is generally high before induction, and H4 acetylation shows a promoter-specific increase. Interestingly, there is a depletion of histone H3 under maximal induction, explaining an apparent decrease of H3-K4 tri-methylation and H3-K79 di-methylation. Pol II is found enriched on some promoters under basal conditions, unlike TBP and p300, which are recruited selectively. Most genes are bound by XBP-1 after induction, some before induction, presumably by the inactive isoform. ATF6 and CHOP associate to largely different set of genes. C/EBPbeta is selective and binding to the CHOP promoter precedes that of XBP-1, ATF6 and CHOP. Finally, one of the ER-stress inducible genes analyzed, HRD1, is not bound by any of these factors. Among the constitutive TFs, NF-Y, but not Sp1, is found on all genes before induction. Intriguingly, siRNA interference of the NF-YB subunit indicates transcriptional impairment of some, but not all genes. These data highlight a previously unappreciated complexity of TFs binding and epigenetic changes, pointing to different TFs-specific pathways within this broad response.
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