ArticleNucleic acids research2006
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Analysis of susceptible genes and chromosome loci for lung cancers by automated gene prediction tools and genome scanning meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Meta-analysis approach identifies candidate genes and associated molecular networks for type-2 diabetes mellitus.BMC genomics · 2008Pooled it
- Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study.The American journal of clinical nutrition · 2019Trial
- BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA.Cell death & disease · 2024Article
- Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes.Biology · 2021Article
- Article
- The pattern of plasma BCAA concentration and liverAnimal models and experimental medicine · 2018Article
- Identification of oral cancer related candidate genes by integrating protein-protein interactions, gene ontology, pathway analysis and immunohistochemistry.Scientific reports · 2017Article
- Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.Molecular metabolism · 2016Article
- The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism.Nutrients · 2016Review
- Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults.Metabolomics : Official journal of the Metabolomic Society · 2016Article
- Transcriptome Profiles Using Next-Generation Sequencing Reveal Liver Changes in the Early Stage of Diabetes in Tree Shrew (Tupaia belangeri chinensis).Journal of diabetes research · 2016Article
- MOBAS: identification of disease-associated protein subnetworks using modularity-based scoring.EURASIP journal on bioinformatics & systems biology · 2015Article
- The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.Nutrition & metabolism · 2015Article
- RNA sequencing reveals a slow to fast muscle fiber type transition after olanzapine infusion in rats.PloS one · 2015Article
- The pathogenic role of persistent milk signaling in mTORC1- and milk-microRNA-driven type 2 diabetes mellitus.Current diabetes reviews · 2015Review
- Branched-chain amino acids in metabolic signalling and insulin resistance.Nature reviews. Endocrinology · 2014Review
- Alloisoleucine differentiates the branched-chain aminoacidemia of Zucker and dietary obese rats.Obesity (Silver Spring, Md.) · 2014Article
- A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics.Systems and synthetic biology · 2014Article
- Quantification of branched-chain keto acids in tissue by ultra fast liquid chromatography-mass spectrometry.Analytical biochemistry · 2013Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Genome-wide experimental methods to identify disease genes, such as linkage analysis and association studies, generate increasingly large candidate gene sets for which comprehensive empirical analysis is impractical. Computational methods employ data from a variety of sources to identify the most likely candidate disease genes from these gene sets. Here, we review seven independent computational disease gene prioritization methods, and then apply them in concert to the analysis of 9556 positional candidate genes for type 2 diabetes (T2D) and the related trait obesity. We generate and analyse a list of nine primary candidate genes for T2D genes and five for obesity. Two genes, LPL and BCKDHA, are common to these two sets. We also present a set of secondary candidates for T2D (94 genes) and for obesity (116 genes) with 58 genes in common to both diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.