ArticleProceedings of the National Academy of Sciences of the United States of America2006
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Trans-ethnic genome-wide association study of severe COVID-19.Communications biology · 2021Pooled it
- Trial
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- Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors.Molecular therapy. Methods & clinical development · 2023Article
- Participation of Single-Nucleotide Variants inPathogens (Basel, Switzerland) · 2023Review
- Hyperinflammatory Immune Response in COVID-19: Host Genetic Factors in Pyrin Inflammasome and Immunity to Virus in a Spanish Population from Majorca Island.Biomedicines · 2023Article
- Association ofInternational journal of molecular sciences · 2023Article
- Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.Nature genetics · 2022Article
- Association of Interleukin GenesGenes · 2022Article
- Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.Frontiers in genetics · 2022Article
- Integrative analysis identifies the association betweenNeurology. Genetics · 2020Article
- Interferon-α inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh-7 cells transfected with hepatitis B virus X gene-expressing lentivirus.Experimental and therapeutic medicine · 2017Article
- Comparison ofIranian journal of pathology · 2017Article
- Treatment of hepatitis B virus: an update.Future microbiology · 2016Review
- Screening and treatment of hepatitis B virus to prevent liver cancer in Africa.Hepatic oncology · 2015Article
- Article
- Detection of allele specific differences in IFNL3 (IL28B) mRNA expression.BMC medical genetics · 2014Article
- Basis of HBV persistence and new treatment options.Hepatology international · 2014Article
- Relationship between cytokine gene polymorphisms and chronic hepatitis B virus infection.World journal of gastroenterology · 2014Review
- Genomics and infectious disease: a call to identify the ethical, legal and social implications for public health and clinical practice.Genome medicine · 2014Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 3 countries.
Funding
Abstract
Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type I IFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-lambdas, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.