ArticleBMC infectious diseases2006
Soluble egg antigen of Schistosoma Haematobium induces HCV replication in PBMC from patients with chronic HCV infection.
Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review.PLoS pathogens · 2021Pooled it
- Urogenital schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents.Scientific reports · 2019Article
- Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients.PLoS neglected tropical diseases · 2016Article
- Schistosomiasis, hepatitis B and hepatitis C co-infection.Virology journal · 2015Review
- Interaction Between the Neglected Tropical Disease Human Schistosomiasis and HCV Infection in Egypt: a Puzzling Relationship.Journal of clinical and translational hepatology · 2014Review
- Schistosomiasis does not affect the outcome of HCV infection in genotype 4-infected patients.The American journal of tropical medicine and hygiene · 2014Article
- In vitro inhibition of hepatitis C virus by antisense oligonucleotides in PBMC compared to hepatoma cells.BioMed research international · 2014Article
- Coinfection with hepatitis C virus and schistosomiasis: fibrosis and treatment response.World journal of gastroenterology · 2013Article
- Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection.World journal of hepatology · 2013Article
- Schistosome egg antigens elicit a proinflammatory response by trophoblast cells of the human placenta.Infection and immunity · 2013Article
- Heterogeneity and new epitopes of hepatitis C virus genotype 4.Hepatitis monthly · 2013Article
- Prevalence of occult hepatitis C virus in egyptian patients with chronic lymphoproliferative disorders.Hepatitis research and treatment · 2012Article
- Schistosome: its benefit and harm in patients suffering from concomitant diseases.Journal of biomedicine & biotechnology · 2011Review
- Impact of human schistosomiasis in sub-Saharan Africa.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was conducted to examine, in vitro , the effect of soluble egg antigen (SEA) of S. haematobium on intracellular HCV RNA load in peripheral mononuclear cells (PBMC) as well as on cell proliferation in patients with chronic HCV infection.
methodsPBMC from 26 patients with chronic HCV infection were cultured for 72 hours in presence and absence of 50 mug SEA/ml medium. Intracellular HCV RNA quantification of plus and minus strands was assessed before and after stimulation. PBMC from five healthy subjects were cultured for 7 days, flow cytometric analysis of DNA content was used to assess the mitogenic effect of SEA on PBMC proliferation compared to phytoheamaglutinine (PHA).
resultsQuantification of the intracellular viral load showed increased copy number/cell of both or either viral strands after induction with SEA in 18 of 26 patients (69.2%) thus indicating stimulation of viral replication. Flow cytometric analysis showed that mean +/- S.D. of percent values of cell proliferation was induced from 3.2 +/- 1.5% in un-stimulated cells to 16.7 +/- 2.5 % and 16.84 +/- 1.7 % in cells stimulated with PHA and SEA respectively.
conclusionthe present study supports earlier reports on SEA proliferative activity on PBMC and provides a strong evidence that the higher morbidity observed in patients co-infected with schistosomiasis and HCV is related, at least in part, to direct stimulation of viral replication by SEA.
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