ArticleMolecular psychiatry2006
Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Changes of Serum Homocysteine and Vitamin B12, but Not Folate Are Correlated With Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Case-Control Studies.Frontiers in psychiatry · 2022Pooled it
- Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis.Molecular psychiatry · 2018Pooled it
- Genome-wide association study of obsessive-compulsive disorder.Molecular psychiatry · 2013Pooled it
- The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- De novo mutations identified by whole-genome sequencing implicate chromatin modifications in obsessive-compulsive disorder.Science advances · 2022Article
- Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity.Frontiers in psychiatry · 2021Review
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Genetics of obsessive-compulsive disorder.Indian journal of psychiatry · 2019Review
- Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology.Neuroscience · 2017Review
- Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression.Scientific reports · 2016Article
- Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.Scientific reports · 2016Article
- Whole-genome association analysis of treatment response in obsessive-compulsive disorder.Molecular psychiatry · 2016Article
- Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.Molecular psychiatry · 2015Article
- The neurobiological link between OCD and ADHD.Attention deficit and hyperactivity disorders · 2014Review
- Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective.Nature reviews. Neuroscience · 2014Review
- An inherited small microdeletion at 15q13.3 in a patient with early-onset obsessive-compulsive disorder.PloS one · 2014Article
- Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.PLoS genetics · 2013Article
- Interaction of SLC1A1 gene variants and life stress on pharmacological resistance in obsessive-compulsive disorder.The pharmacogenomics journal · 2013Article
- Association between SLC1A1 gene and early-onset OCD in the Han Chinese population: a case-control study.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this disorder, although specific genes have yet to be identified. Here, we present the first large-scale model-free linkage analysis of both extended and nuclear families using both 'broad' (definite and probable diagnoses) and 'narrow' (definite only) definitions of OCD. We conducted a genome-scan analysis of 219 families collected as part of the OCD Collaborative Genetics Study. Suggestive linkage signals were revealed by multipoint analysis on chromosomes 3q27-28 (P=0.0003), 6q (P=0.003), 7p (P=0.001), 1q (P=0.003), and 15q (P=0.006). Using the 'broad' OCD definition, we observed the strongest evidence for linkage on chromosome 3q27-28. The maximum overall Kong and Cox LODall score (2.67) occurred at D3S1262 and D3S2398, and simulation based P-values for these two signals were 0.0003 and 0.0004, respectively, although for both signals, the simulation-based genome-wide significance levels were 0.055. Covariate-linkage analyses implicated a possible role of gene(s) on chromosome 1 in increasing the risk for an earlier onset form of OCD. We are currently pursuing fine mapping in the five regions giving suggestive signals, with a particular focus on 3q27-28. Given probable etiologic heterogeneity in OCD, mapping gene(s) involved in the disorder may be enhanced by replication studies, large-scale family-based linkage studies, and the application of novel statistical methods.
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