ArticleProceedings of the National Academy of Sciences of the United States of America2006
Positive selection driving diversification in plant secondary metabolism.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
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Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of genome duplication on secondary metabolite composition in non-cultivated species: a systematic meta-analysis.Annals of botany · 2020Pooled it
- Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding.BMC plant biology · 2026Article
- Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster.Science advances · 2024Article
- Universal signatures of transposable element compartmentalization across eukaryotic genomes.bioRxiv : the preprint server for biology · 2024Article
- Genetic basis and selection of glyceollin elicitation in wild soybean.Frontiers in plant science · 2024Article
- Soil variation among natural habitats alters glucosinolate content in a wild perennial mustard.Journal of experimental botany · 2023Article
- Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin fromMolecules (Basel, Switzerland) · 2022Article
- Structural Studies of Aliphatic Glucosinolate Chain-Elongation Enzymes.Antioxidants (Basel, Switzerland) · 2021Review
- The Genetic Base for Peanut Height-Related Traits Revealed by a Meta-Analysis.Plants (Basel, Switzerland) · 2021Article
- Article
- Drivers of metabolic diversification: how dynamic genomic neighbourhoods generate new biosynthetic pathways in the Brassicaceae.The New phytologist · 2020Article
- mGWAS Uncovers Gln-Glucosinolate Seed-Specific Interaction and its Role in Metabolic Homeostasis.Plant physiology · 2020Article
- Low-Copy Genes in Terpenoid Metabolism: The Evolution and Expression ofPlants (Basel, Switzerland) · 2020Article
- Article
- Genomic Origin and Diversification of the Glucosinolate MAM Locus.Frontiers in plant science · 2020Article
- The evolution of metabolism: How to test evolutionary hypotheses at the genomic level.Computational and structural biotechnology journal · 2020Review
- Parallel selection on ecologically relevant gene functions in the transcriptomes of highly diversifying salmonids.BMC genomics · 2019Article
- Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis ofBioscience reports · 2019Article
37 more citing papers are in PubMed but not listed here.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate synthases (MAM) encoded at the MAM gene cluster control an early step in the biosynthesis of glucosinolates and, therefore, are central to the diversification of glucosinolate metabolism. We sequenced bacterial artificial chromosomes containing the MAM cluster from several Arabidopsis relatives, conducted enzyme assays with heterologously expressed MAM genes, and analyzed MAM nucleotide variation patterns. Our results show that gene duplication, neofunctionalization, and positive selection provide the mechanism for biochemical adaptation in plant defense. These processes occur repeatedly in the history of the MAM gene family, indicating their fundamental importance for the evolution of plant metabolic diversity both within and among species.
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