ArticleProceedings of the National Academy of Sciences of the United States of America2006
The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
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160 citing papers in PubMed.
- Comparative genomics and methylome profiling ofMicrobial genomics · 2026Article
- Limits to the evolution of metabolic dependency in spatially structured microbial communities.iScience · 2026Article
- Global transcriptional regulation by the CodY gene: identification of critical compounds that enhance oxidative stress resistance in Lactobacillus delbrueckii subsp. Bulgaricus.BMC microbiology · 2025Article
- Genomic analysis of3 Biotech · 2025Article
- Genomic insights into habitat adaptation of Lactobacillus species.World journal of microbiology & biotechnology · 2025Article
- Does strain-level persistence of lactobacilli in long-term back-slopped sourdoughs inform on domestication of food-fermenting lactic acid bacteria?Applied and environmental microbiology · 2024Article
- Genomic and phenotypic imprints of microbial domestication on cheese starter cultures.Nature communications · 2024Article
- Genomic Characterization of WildMicroorganisms · 2024Article
- Assessing probiotic viability in mixed species yogurt using a novel propidium monoazide (PMAxx)-quantitative PCR method.Frontiers in microbiology · 2024Article
- Inulin increases the EPS biosynthesis of Lactobacillus delbrueckii ssp. bulgaricus LDB-C1.Biotechnology letters · 2023Article
- Special Issue "An Update on Lactobacillus": Editorial.Microorganisms · 2023Article
- Reduction, evolutionary pattern and positive selection of genes encoding formate dehydrogenase in Wood-Ljungdahl pathway of gastrointestinal acetogens suggests their adaptation to formate-rich habitats.Environmental microbiology reports · 2023Article
- Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria.Food science and biotechnology · 2023Review
- Subspecies-level genome comparison of Lactobacillus delbrueckii.Scientific reports · 2023Article
- Complete Genome Sequence of Lactobacillus bulgaricus VHProbi R03, a Potential Fermentation Strain Isolated from Fermented Milk.Microbiology resource announcements · 2023Article
- Differential Amino Acid Uptake and Depletion in Mono-Cultures and Co-Cultures ofMicroorganisms · 2022Article
- Genome-Scale Metabolic Modeling Combined with Transcriptome Profiling Provides Mechanistic Understanding of Streptococcus thermophilus CH8 Metabolism.Applied and environmental microbiology · 2022Article
- Calcium DeterminesApplied and environmental microbiology · 2022Article
- The periodic table of fermented foods: limitations and opportunities.Applied microbiology and biotechnology · 2022Review
- Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine Bifidobacterium Species.Microbial physiology · 2022Article
100 more citing papers are in PubMed but not listed here.
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21 authors.
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Abstract
Lactobacillus delbrueckii ssp. bulgaricus (L. bulgaricus) is a representative of the group of lactic acid-producing bacteria, mainly known for its worldwide application in yogurt production. The genome sequence of this bacterium has been determined and shows the signs of ongoing specialization, with a substantial number of pseudogenes and incomplete metabolic pathways and relatively few regulatory functions. Several unique features of the L. bulgaricus genome support the hypothesis that the genome is in a phase of rapid evolution. (i) Exceptionally high numbers of rRNA and tRNA genes with regard to genome size may indicate that the L. bulgaricus genome has known a recent phase of important size reduction, in agreement with the observed high frequency of gene inactivation and elimination; (ii) a much higher GC content at codon position 3 than expected on the basis of the overall GC content suggests that the composition of the genome is evolving toward a higher GC content; and (iii) the presence of a 47.5-kbp inverted repeat in the replication termination region, an extremely rare feature in bacterial genomes, may be interpreted as a transient stage in genome evolution. The results indicate the adaptation of L. bulgaricus from a plant-associated habitat to the stable protein and lactose-rich milk environment through the loss of superfluous functions and protocooperation with Streptococcus thermophilus.
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