ArticleProceedings of the National Academy of Sciences of the United States of America2006
Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 89 citations in OpenAlex.
- Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8Immunology and cell biology · 2026Article
- Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Simultaneous coinfection with influenza virus and an arbovirus impedes influenza-specific but not Semliki Forest virus-specific responses.Immunology and cell biology · 2025Article
- Memory inflation: Beyond the acute phase of viral infection.Cell proliferation · 2024Review
- The Memory-CD8+-T-Cell Response to Conserved Influenza Virus Epitopes in Mice Is Not Influenced by Time Since Previous Infection.Vaccines · 2024Article
- Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses.Nature communications · 2024Article
- Methionine enkephalin(MENK) upregulated memory T cells in anti-influenza response.BMC immunology · 2023Article
- Cycling and activated CD8BMC immunology · 2022Article
- Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires.International journal of molecular sciences · 2021Article
- Area under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets.Cold Spring Harbor perspectives in biology · 2020Review
- Viral burden, inflammatory milieu and CD8Influenza and other respiratory viruses · 2020Article
- The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease.Viral immunology · 2020Review
- Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8Frontiers in immunology · 2019Article
- Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.The Journal of clinical investigation · 2018Article
- T Cell Receptor Profiling in Type 1 Diabetes.Current diabetes reports · 2017Review
- The memory of a killer T cell: models of CD8(+) T cell differentiation.Immunology and cell biology · 2016Review
- SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.Immunology and cell biology · 2015Article
- Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.The Journal of infectious diseases · 2015Article
- Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells.Nature communications · 2015Article
- TCR Signaling in T Cell Memory.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Single-cell analysis of endogenous, primary CD8(+) T cell responses to the influenza D(b)NP(366) and D(b)PA(224) epitopes indicates that prominent clonotypes bearing "public" or "shared" T cell receptors (TCRs) subset early into CD62L(hi) and CD62L(lo) populations. The CD62L(lo) effectors divide more and are rapidly eliminated during the contraction phase, whereas stable CD62L(hi) memory populations persist in the long-term. Reflecting the high frequency of small CD62L(hi) clones expressing "private" TCRs, the TCR diversity range per mouse is generally two times higher within the CD62L(hi)CD8(+)D(b)NP(366)(+) set (1.6 times higher for CD62L(hi)CD8(+)D(b)PA(224)(+)) from 8 to >180 days after antigen challenge. Memory CD8(+)CD62L(hi) T cell precursors thus segregate from the outset into populations expressing "best-fit" and "suboptimal" TCR characteristics, with this pattern being maintained stably thereafter. Hence, our analysis suggests that early establishment of influenza-specific memory within the CD8(+)CD62L(hi) subset preserves clonal diversity and prevents "overdominance" by a few public, or shared, clones.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.