ArticleProceedings of the National Academy of Sciences of the United States of America2006
Compartmentalized signaling of Ras in fission yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- Targeting the cell membrane in established and emerging model organisms.bioRxiv : the preprint server for biology · 2025Article
- Design principles for selective polarization of PAR proteins by cortical flows.The Journal of cell biology · 2023Article
- Protein S-palmitoylation regulates different stages of meiosis inLife science alliance · 2023Article
- Post-embryonic endogenous expression and localization of LET-60/Ras inmicroPublication biology · 2023Article
- Post-translational modification of RAS proteins.Current opinion in structural biology · 2021Review
- Cell patterning by secretion-induced plasma membrane flows.Science advances · 2021Article
- Ras isoform-specific expression, chromatin accessibility, and signaling.Biophysical reviews · 2021Review
- Spatial regulation and generation of diversity in signaling pathways.Journal of biosciences · 2021Review
- Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Conserved NDR/LATS kinase controls RAS GTPase activity to regulate cell growth and chronological lifespan.Molecular biology of the cell · 2019Article
- Posttranslational Modifications of RAS Proteins.Cold Spring Harbor perspectives in medicine · 2018Review
- To finish things well: cysteine methylation ensures selective GTPase membrane localization and signalling.Current genetics · 2018Review
- Membrane Thickness as a Key Factor Contributing to the Activation of Osmosensors and Essential Ras Signaling Pathways.Frontiers in cell and developmental biology · 2018Review
- Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast.Scientific reports · 2017Article
- Protein S-palmitoylation in cellular differentiation.Biochemical Society transactions · 2017Review
- RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Comparative proteomic analysis of compartmentalised Ras signalling.Scientific reports · 2015Article
- Parameter identification problems in the modelling of cell motility.Journal of mathematical biology · 2015Article
- Orchestration of Morphogenesis in Filamentous Fungi: Conserved Roles for Ras Signaling Networks.Fungal biology reviews · 2015Article
7 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Compartment-specific Ras signaling is an emerging paradigm that may explain the multiplex outputs from a single GTPase. The fission yeast, Schizosaccharomyces pombe, affords a simple system in which to study Ras signaling because it has a single Ras protein, Ras1, that regulates two distinct pathways: one that controls mating through a Byr2-mitogen-activated protein kinase cascade and one that signals through Scd1-Cdc42 to maintain elongated cell morphology. We generated Ras1 mutants that are restricted to either the endomembrane or the plasma membrane. Protein binding studies showed that each could interact with the effectors of both pathways. However, when examined in ras1 null cells, endomembrane-restricted Ras1 supported morphology but not mating, and, conversely, plasma membrane-restricted Ras1 supported mating but did not signal to Scd1-Cdc42. These observations provide a striking demonstration of compartment-specific Ras signaling and indicate that spatial specificity in the Ras pathway is evolutionarily conserved.
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