ArticleThe Journal of experimental medicine2006
Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.The Journal of experimental medicine · 2013Trial
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- E proteins control the development of NKγδT cells through their invariant T cell receptor.Nature communications · 2024Article
- Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection.Frontiers in immunology · 2024Article
- γδ T cells: origin and fate, subsets, diseases and immunotherapy.Signal transduction and targeted therapy · 2023Review
- Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.Frontiers in immunology · 2023Article
- Understanding the Notch Signaling Pathway in Acute Myeloid Leukemia Stem Cells: From Hematopoiesis to Neoplasia.Cancers · 2022Review
- Prospects for Development of Induced Pluripotent Stem Cell-Derived CAR-Targeted Immunotherapies.Archivum immunologiae et therapiae experimentalis · 2021Review
- Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R[Formula: see text]Scientific reports · 2021Article
- Developing T cells form an immunological synapse for passage through the β-selection checkpoint.The Journal of cell biology · 2021Article
- Article
- Get in Touch With Dendritic Epithelial T Cells!Frontiers in immunology · 2020Review
- Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12.Nature immunology · 2019Article
- Induced Pluripotent Stem Cell (iPSC)-Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges.Current hematologic malignancy reports · 2019Review
- γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.Current opinion in immunology · 2019Review
- Conditional Deletion of the V-ATPase a2-Subunit Disrupts Intrathymic T Cell Development.Frontiers in immunology · 2019Article
- Development of Unconventional T Cells Controlled by MicroRNA.Frontiers in immunology · 2019Review
- Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells.Science immunology · 2018Article
- Forging T-Lymphocyte Identity: Intersecting Networks of Transcriptional Control.Advances in immunology · 2016Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Thymic precursors expressing the pre-T cell receptor (TCR), the gammadeltaTCR, or the alphabetaTCR can all enter the CD4+ 8+ alphabeta lineage, albeit with different efficacy. Here it is shown that proliferation and differentiation of precursors with the different TCRs into alphabeta lineage cells require Notch signaling at the DN3 stage of thymic development. At the DN4 stage, Notch signaling still significantly contributes to the generation of alphabeta T cells. In particular, in alphabeta lineage commitment, the pre-TCR synergizes more efficiently with Notch signals than the other two TCRs, whereas gammadeltaTCR-expressing cells can survive and expand in the absence of Notch signals, even though Notch signaling enhances their proliferation. These observations suggest a new model of alphabeta versus gammadelta lineage choice in which lineage fate is determined by the extent of synergy between TCR and Notch signaling and in which the evolutionarily recent advent of the cell-autonomously signaling pre-TCR increased the efficacy of alphabeta T cell generation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.