ArticleExperimental lung research
Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium.
Article in Experimental lung research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure.Scientific reports · 2025Article
- Modeling the effects of cigarette smoke extract on influenza B virus infections in mice.Frontiers in immunology · 2023Article
- Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-Journal of immunology research · 2021Article
- Exposure to Cigarette Smoke Enhances Pneumococcal Transmission Among Littermates in an Infant Mouse Model.Frontiers in cellular and infection microbiology · 2021Article
- p19Biomolecules · 2020Article
- WDPCP Modulates Cilia Beating Through the MAPK/ERK Pathway in Chronic Rhinosinusitis With Nasal Polyps.Frontiers in cell and developmental biology · 2020Article
- Critical role of interleukin-23 in development of asthma promoted by cigarette smoke.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography.Scientific reports · 2017Article
- Cigarette Smoke Impairs AScientific reports · 2017Article
- Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages.Oncogene · 2015Article
- Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Article
- Particulate matter in cigarette smoke increases ciliary axoneme beating through mechanical stimulation.Journal of aerosol medicine and pulmonary drug delivery · 2012Article
- Alcohol reduces airway hyperresponsiveness (AHR) and allergic airway inflammation in mice.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Long-term cigarette smoke exposure in a mouse model of ciliated epithelial cell function.American journal of respiratory cell and molecular biology · 2010Article
- Regulation of Human MUC7 Mucin Gene Expression by Cigarette Smoke Extract or Cigarette Smoke and Pseudomonas aeruginosa Lipopolysaccharide in Human Airway Epithelial Cells and in MUC7 Transgenic Mice.The open respiratory medicine journal · 2010Article
- Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.Respiratory research · 2009Article
- Increased nasal epithelial ciliary beat frequency associated with lifestyle tobacco smoke exposure.Inhalation toxicology · 2009Article
- Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice.American journal of physiology. Lung cellular and molecular physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this study the authors compared the affect of vapor phase cigarette smoke (CS) versus cigarette smoke extract (CSE) on the lungs and upper airway of C57BL/6 mice. The authors found that CSE treatment significantly increased neutrophil influx (P < .001), baseline ciliary beat frequency (CBF) (P < .05), and protein kinase C activity compared to CS and controls. Isoproterenol increased CBF with CS exposure, but decreased CBF with CSE (P < .01). Isoproterenol increased protein kinase A (PKA) activity in all groups except CSE. CSE exposure induced inflammatory cell bronchiolitis. These data indicate that CSE exposure has differential effects on the lungs and tracheal epithelium compared to CS exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.