ArticleHormones and behavior2006
Individual differences in estrogen receptor alpha in select brain nuclei are associated with individual differences in aggression.
Article in Hormones and behavior, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 104 citations in OpenAlex.
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- Estrous Cycle-Dependent Modulation of Sexual Receptivity in Female Mice by Estrogen Receptor Beta-Expressing Cells in the Dorsal Raphe Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Bidirectional relationships between testosterone and aggression: a critical analysis of four predictions.Integrative and comparative biology · 2022Article
- Anti-anger Effects of Herbal Medicine: A Mini-Review of Rat Studies.Chinese journal of integrative medicine · 2022Review
- Neuroendocrine regulation of female aggression.Frontiers in endocrinology · 2022Review
- Correction of vasopressin deficit in the lateral septum ameliorates social deficits of mouse autism model.The Journal of clinical investigation · 2021Article
- Inside the supergene of the bird with four sexes.Hormones and behavior · 2020Review
- Expression ofPrzeglad menopauzalny = Menopause review · 2019Article
- Evaluating testosterone as a phenotypic integrator: From tissues to individuals to species.Molecular and cellular endocrinology · 2019Review
- Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-DefectiveInternational journal of molecular sciences · 2019Article
- Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats.Neuropharmacology · 2019Review
- CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety.Alcohol (Fayetteville, N.Y.) · 2018Review
- Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism.Hormones and behavior · 2018Article
- Aggressive behaviours track transitions in seasonal phenotypes of female Siberian hamsters.Functional ecology · 2017Article
- Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders.Molecular psychiatry · 2016Review
- UV-filter benzophenone-3 inhibits agonistic behavior in male Siamese fighting fish (Betta splendens).Ecotoxicology (London, England) · 2016Article
- Estrogen Receptor Alpha Distribution and Expression in the Social Neural Network of Monogamous and Polygynous Peromyscus.PloS one · 2016Article
- Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs.Integrative and comparative biology · 2015Review
- Natural variation in paternal behavior is associated with central estrogen receptor alpha and oxytocin levels.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Steroid hormones play an important role in modulating social behavior in many species. Estrogens are thought to act on an interconnected network of hypothalamic and limbic brain areas to affect aggressive behavior, although the specific nuclei unknown remain unspecified. We show that individual variation in estrogen receptor alpha (ERalpha) immunoreactivity in the lateral septum (LS), ventral bed nucleus of the stria terminalis (vBNST), and anterior hypothalamus (AHA) of CD-1 mice is positively correlated with aggressive behavior. When males were treated with fadrozole (an aromatase inhibitor), aggressive behavior was reduced, although castration did not reduce aggression. These results suggest that estrogens modulate aggressive behavior by acting on a circuit that includes the LS, vBNST, and AHA and that the source of estrogens is non-gonadal. Fadrozole also decreased c-fos expression in the lateral septum following aggressive encounters. Although the effects of estrogen on aggression appear to involve regulation of neuronal activity in the LS, additional processes are likely involved. These results suggest that estrogen acts in a specific subset of a complex network of nuclei to affect aggressive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.