ArticleBMC developmental biology2006
MATER protein expression and intracellular localization throughout folliculogenesis and preimplantation embryo development in the bovine.
Article in BMC developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 76 citations in OpenAlex.
- Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle.Scientific reports · 2025Article
- Padi6 expression patterns in buffalo oocytes and preimplantation embryos.Animal reproduction · 2024Article
- Growth hormone treatment improves the development of follicles and oocytes in prepubertal lambs.Journal of ovarian research · 2023Article
- Pre-Implantation Bovine Embryo Evaluation-From Optics to Omics and Beyond.Animals : an open access journal from MDPI · 2023Review
- The neglected part of early embryonic development: maternal protein degradation.Cellular and molecular life sciences : CMLS · 2020Review
- Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced byMicroorganisms · 2020Article
- Integrated Analysis of Quantitative Proteome and Transcriptional Profiles Reveals the Dynamic Function of Maternally Expressed Proteins After Parthenogenetic Activation of Buffalo Oocyte.Molecular & cellular proteomics : MCP · 2018Article
- ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos.Scientific reports · 2016Article
- Maternal control of early embryogenesis in mammals.Reproduction, fertility, and development · 2015Review
- Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos.Nucleic acids research · 2013Article
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- NLRP5 mediates mitochondrial function in mouse oocytes and embryos.Biology of reproduction · 2012Article
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- Molecular cloning and expression of bovine nucleoplasmin 2 (NPM2): a maternal effect gene regulated by miR-181a.Reproductive biology and endocrinology : RB&E · 2011Article
- Effects of bone morphogenic protein 4 (BMP4) and its inhibitor, Noggin, on in vitro maturation and culture of bovine preimplantation embryos.Reproductive biology and endocrinology : RB&E · 2011Article
- Proteomics-based systems biology modeling of bovine germinal vesicle stage oocyte and cumulus cell interaction.PloS one · 2010Article
- Expression analysis of the NLRP gene family suggests a role in human preimplantation development.PloS one · 2008Article
- The NALP3/Cryopyrin-inflammasome complex is expressed in LPS-induced ocular inflammation.Mediators of inflammation · 2008Article
- Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo.BMC developmental biology · 2007Article
- JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMater (Maternal Antigen that Embryos Require), also known as Nalp5 (NACHT, leucine rich repeat and PYD containing 5), is an oocyte-specific maternal effect gene required for early embryonic development beyond the two-cell stage in mouse. We previously characterized the bovine orthologue MATER as an oocyte marker gene in cattle, and this gene was recently assigned to a QTL region for reproductive traits.
resultsHere we have analyzed gene expression during folliculogenesis and preimplantation embryo development. In situ hybridization and immunohistochemistry on bovine ovarian section revealed that both the transcript and protein are restricted to the oocyte from primary follicles onwards, and accumulate in the oocyte cytoplasm during follicle growth. In immature oocytes, cytoplasmic, and more precisely cytosolic localization of MATER was confirmed by immunohistochemistry coupled with confocal microscopy and immunogold electron microscopy. By real-time PCR, MATER messenger RNA was observed to decrease strongly during maturation, and progressively during the embryo cleavage stages; it was hardly detected in morulae and blastocysts. The protein persisted after fertilization up until the blastocyst stage, and was mostly degraded after hatching. A similar predominantly cytoplasmic localization was observed in blastomeres from embryos up to 8-cells, with an apparent concentration near the nuclear membrane.
conclusionAltogether, these expression patterns are consistent with bovine MATER protein being an oocyte specific maternal effect factor as in mouse.
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