ArticleBMC microbiology2006
Comparative genomics of regulation of heavy metal resistance in Eubacteria.
Article in BMC microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- A survey of bacterial and fungal community structure and functions in two long-term metalliferous soil habitats.Scientific reports · 2025Article
- Regulatory Element Analysis and Comparative Genomics Study of Heavy Metal-Resistant Genes in the Complete GenomeBioinformatics and biology insights · 2024Article
- Validation and calibration of a novel GEM biosensor for specific detection of CdBMC biotechnology · 2023Article
- Chimeric MerR-Family Regulators and Logic Elements for the Design of Metal Sensitive Genetic Circuits inACS synthetic biology · 2023Article
- Unraveling the Underlying Heavy Metal Detoxification Mechanisms ofMicroorganisms · 2021Review
- Genomics Insights intoGenes · 2021Article
- Metal-Resistance in Bacteria: Why Care?Genes · 2020Article
- The CzcCBA Efflux System Requires the CadA P-Type ATPase for Timely Expression Upon Zinc Excess inFrontiers in microbiology · 2020Article
- Draft Genome Sequence of the Novel Enterobacter cloacae Strain amazonensis, a Highly Heavy Metal-Resistant Bacterium from a Contaminated Stream in Amazonas, Brazil.Genome announcements · 2018Article
- ZntR positively regulates T6SS4 expression in Yersinia pseudotuberculosis.Journal of microbiology (Seoul, Korea) · 2017Article
- Expression Analysis of Ni- and V-Associated Resistance Genes in a Bacillus megaterium Strain Isolated from a Mining Site.Current microbiology · 2016Article
- Host, pathogen and the environment: the case of Macrobrachium rosenbergii, Vibrio parahaemolyticus and magnesium.Gut pathogens · 2016Review
- TheFrontiers in microbiology · 2016Article
- Article
- Aerobic transformation of cadmium through metal sulfide biosynthesis in photosynthetic microorganisms.BMC microbiology · 2013Article
- Cysteine coordination of Pb(II) is involved in the PbrR-dependent activation of the lead-resistance promoter, PpbrA, from Cupriavidus metallidurans CH34.BMC microbiology · 2012Article
- Comparative genomic reconstruction of transcriptional networks controlling central metabolism in the Shewanella genus.BMC genomics · 2011Article
- Article
- General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se.The Journal of biological chemistry · 2010Article
- RegPrecise: a database of curated genomic inferences of transcriptional regulatory interactions in prokaryotes.Nucleic acids research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeavy metal resistance (HMR) in Eubacteria is regulated by a variety of systems including transcription factors from the MerR family (COG0789). The HMR systems are characterized by the complex signal structure (strong palindrome within a 19 or 20 bp promoter spacer), and usually consist of transporter and regulator genes. Some HMR regulons also include detoxification systems. The number of sequenced bacterial genomes is constantly increasing and even though HMR resistance regulons of the COG0789 type usually consist of few genes per genome, the computational analysis may contribute to the understanding of the cellular systems of metal detoxification.
resultsWe studied the mercury (MerR), copper (CueR and HmrR), cadmium (CadR), lead (PbrR), and zinc (ZntR) resistance systems and demonstrated that combining protein sequence analysis and analysis of DNA regulatory signals it was possible to distinguish metal-dependent members of COG0789, assign specificity towards particular metals to uncharacterized loci, and find new genes involved in the metal resistance, in particular, multicopper oxidase and copper chaperones, candidate cytochromes from the copper regulon, new cadmium transporters and, possibly, glutathione-S-transferases.
conclusionOur data indicate that the specificity of the COG0789 systems can be determined combining phylogenetic analysis and identification of DNA regulatory sites. Taking into account signal structure, we can adequately identify genes that are activated using the DNA bending-unbending mechanism. In the case of regulon members that do not reside in single loci, analysis of potential regulatory sites could be crucial for the correct annotation and prediction of the specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.