ArticleJournal of molecular evolution2006
GC content evolution of the human and mouse genomes: insights from the study of processed pseudogenes in regions of different recombination rates.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- De Novo Assembly and Characterization of the Transcriptome of an Omnivorous Camel Cricket (International journal of molecular sciences · 2023Article
- Evaluation of Ancestral Sequence Reconstruction Methods to Infer Nonstationary Patterns of Nucleotide Substitution.Genetics · 2015Article
- Evidence for widespread GC-biased gene conversion in eukaryotes.Genome biology and evolution · 2012Article
- Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots.Genome biology and evolution · 2011Article
- The role of the effective population size in compensatory evolution.Genome biology and evolution · 2011Article
- The mutational spectrum of non-CpG DNA varies with CpG content.Genome research · 2010Article
- GC content and recombination: reassessing the causal effects for the Saccharomyces cerevisiae genome.Genetics · 2009Article
- Reduced purifying selection prevails over positive selection in human copy number variant evolution.Genome research · 2008Article
- The correlation between recombination rate and dinucleotide bias in Drosophila melanogaster.Journal of molecular evolution · 2008Article
- CpG dinucleotides and the mutation rate of non-CpG DNA.Genome research · 2008Article
- The impact of recombination on nucleotide substitutions in the human genome.PLoS genetics · 2008Article
- Article
- Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprints with models of stem cell differentiation.Genome biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Processed pseudogenes are generated by reverse transcription of a functional gene. They are generally nonfunctional after their insertion and, as a consequence, are no longer subjected to the selective constraints associated with functional genes. Because of this property they can be used as neutral markers in molecular evolution. In this work, we investigated the relationship between the evolution of GC content in recently inserted processed pseudogenes and the local recombination pattern in two mammalian genomes (human and mouse). We confirmed, using original markers, that recombination drives GC content in the human genome and we demonstrated that this is also true for the mouse genome despite lower recombination rates. Finally, we discussed the consequences on isochores evolution and the contrast between the human and the mouse pattern.
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