ArticlePsychopharmacology2006
Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Cannabidiol enhances consolidation of explicit fear extinction in humans.Psychopharmacology · 2013Trial
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Personality-based intergenerational effects of prenatal THC exposure in an inherited mouse model of social dominance and submissiveness.Scientific reports · 2025Article
- Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study.Developmental cognitive neuroscience · 2024Article
- Effects of cannabidiol on fear conditioning in anxiety disorders: decreased threat expectation during retention, but no enhanced fear re-extinction.Psychopharmacology · 2024Article
- Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects.Psychopharmacology · 2022Article
- Effects of repeated adolescent exposure to cannabis smoke on cognitive outcomes in adulthood.Journal of psychopharmacology (Oxford, England) · 2021Article
- Cannabinoid Modulation of Dopamine Release During Motivation, Periodic Reinforcement, Exploratory Behavior, Habit Formation, and Attention.Frontiers in synaptic neuroscience · 2021Review
- Enhancing effects of acute exposure to cannabis smoke on working memory performance.Neurobiology of learning and memory · 2019Article
- The Effects of Cannabinoids on Executive Functions: Evidence from Cannabis and Synthetic Cannabinoids-A Systematic Review.Brain sciences · 2018Review
- Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Effects of various cannabinoid ligands on choice behaviour in a rat model of gambling.Behavioural pharmacology · 2016Article
- Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol.Frontiers in behavioral neuroscience · 2015Article
- Effects of a novel CB1 agonist on visual attention in male rats: role of strategy and expectancy in task accuracy.Experimental and clinical psychopharmacology · 2013Article
- Modulation of the Endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans.PloS one · 2013Article
- The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats.Psychopharmacology · 2012Article
- Endocannabinoids and the processing of value-related signals.Frontiers in pharmacology · 2012Article
- Effects of endocannabinoid system modulation on cognitive and emotional behavior.Frontiers in behavioral neuroscience · 2011Article
- AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity.Frontiers in behavioral neuroscience · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleCannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear.
objectiveThe present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility using a strategy set-shifting task conducted on a cross maze. MATERIALS AND
methodsIn experiment 1, rats initially were trained to turn left or right while ignoring the visual cue to obtain a food; on the second test day, rats had to inhibit the previously learned rule and approach the cue to obtain the food. In experiment 2, the order of discrimination training was reversed.
resultsAdministration of the cannabinoid CB1 receptor agonist HU-210 before the set-shift on day 2 elicited dose-dependent effects on performance. A 20-microg/kg dose of HU-210 increased perseverative errors, whereas the effects of a lower, 5-microg/kg dose caused differential effects depending on whether rats were required to shift from a response to a visual-cue discrimination strategy or vice versa. Conversely, administration of a 2-mg/kg, but not a 5-mg/kg dose of the CB1 receptor antagonist AM251 reduced perseverative errors.
conclusionsThese data demonstrate a biphasic and dose-sensitive role for the cannabinoid system in behavioral flexibility, which in turn may have clinical implications for the role of the endocannabinoid system in psychiatric disorders where behavioral flexibility is compromised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.