ArticleOncogene2006
Radiation-induced transgenerational alterations in genome stability and DNA damage.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Creating largeFrontiers in plant science · 2025Article
- Effects of space flight on sperm function and integrity: A systematic review.Frontiers in physiology · 2022Review
- Review
- Quantitative modeling of multigenerational effects of chronic ionizing radiation using targeted and nontargeted effects.Scientific reports · 2021Article
- Mutation Induction in Humans and Mice: Where Are We Now?Cancers · 2019Review
- Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance.Epigenomes · 2019Review
- Adverse effects of paternal chemotherapy exposure on the progeny brain: intergenerational chemobrain.Oncotarget · 2018Article
- The Hiroshima/Nagasaki Survivor Studies: Discrepancies Between Results and General Perception.Genetics · 2016Article
- Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1⁺/⁻ mice after paternal irradiation.Oncotarget · 2015Article
- Nuclear and mitochondrial DNA alterations in newborns with prenatal exposure to cigarette smoke.International journal of environmental research and public health · 2015Review
- The Fukushima nuclear accident and the pale grass blue butterfly: evaluating biological effects of long-term low-dose exposures.BMC evolutionary biology · 2013Article
- Epigenetics in radiation biology: a new research frontier.Frontiers in genetics · 2013Article
- What mechanisms/processes underlie radiation-induced genomic instability?Cellular and molecular life sciences : CMLS · 2012Article
- DNMTs are required for delayed genome instability caused by radiation.Epigenetics · 2012Article
- Molecular and organismal changes in offspring of male mice treated with chemical stressors.Environmental and molecular mutagenesis · 2012Article
- Exposure to anticancer drugs can result in transgenerational genomic instability in mice.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The dose and dose-rate effects of paternal irradiation on transgenerational instability in mice: a radiotherapy connection.PloS one · 2012Article
- Article
- Sidestream tobacco smoke is a male germ cell mutagen.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Hsp90 modulates CAG repeat instability in human cells.Cell stress & chaperones · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Mutation induction in directly exposed cells is currently regarded as the main component of the genetic risk of ionizing radiation for humans. However, recent data on the transgenerational increases in mutation rates in the offspring of irradiated parents indicate that the genetic risk could be greater than predicted previously. Here, we have analysed transgenerational changes in mutation rates and DNA damage in the germline and somatic tissues of non-exposed first-generation offspring of irradiated inbred male CBA/Ca and BALB/c mice. Mutation rates at an expanded simple tandem repeat DNA locus and a protein-coding gene (hprt) were significantly elevated in both the germline (sperm) and somatic tissues of all the offspring of irradiated males. The transgenerational changes in mutation rates were attributed to the presence of a persistent subset of endogenous DNA lesions (double- and single-strand breaks), measured by the phosphorylated form of histone H2AX (gamma-H2AX) and alkaline Comet assays. Such remarkable transgenerational destabilization of the F(1) genome may have important implications for cancer aetiology and genetic risk estimates. Our data also provide important clues on the still unknown mechanisms of radiation-induced genomic instability.
Indexed as
Identifiers
16751800What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.