ReviewBone marrow transplantation2006
Adult umbilical cord blood transplantation: a comprehensive review.
Review in Bone marrow transplantation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Effect of methotrexate dose in graft-versus-host disease prophylaxis after single-unit cord blood transplantation in adult acute myeloid leukemia.International journal of hematology · 2021Trial
- Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2008Trial
- Indiscernible benefit of high-resolution HLA typing in improving long-term clinical outcome of unrelated umbilical cord blood transplant.Bone marrow transplantation · 2007Trial
- Short-term methotrexate could reduce early immune reactions and improve outcomes in umbilical cord blood transplantation for adults.Bone marrow transplantation · 2007Trial
- Infection-related mortality after hematopoietic stem cell transplantation in a high antimicrobial resistance setting.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia.Journal of clinical medicine · 2020Article
- Infectious Complications After Umbilical Cord Blood Transplantation for Hematological Malignancy.Open forum infectious diseases · 2019Article
- GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia.Bone marrow transplantation · 2017Article
- Negative selection by apoptosis enriches progenitors in naïve and expanded human umbilical cord blood grafts.Bone marrow transplantation · 2014Article
- Hematopoetic stem cell transplantation in children.Turk pediatri arsivi · 2014Review
- Fetal stem cells and skeletal muscle regeneration: a therapeutic approach.Frontiers in aging neuroscience · 2014Review
- Comparison of the Ex Vivo Expansion of UCB-Derived CD34+ in 3D DBM/MBA Scaffolds with USSC as a Feeder Layer.Iranian journal of basic medical sciences · 2013Article
- Cytomegalovirus infection according to cell source after hematopoietic cell transplantation in pediatric patients.Yonsei medical journal · 2012Article
- Article
- Cord stem-cell transplantation in Ontario: do we need a public bank?Current oncology (Toronto, Ont.) · 2011Article
- Cytomegalovirus in hematopoietic stem cell transplant recipients.Hematology/oncology clinics of North America · 2011Article
- Modulation of AP-endonuclease1 levels associated with hepatic cirrhosis in rat model treated with human umbilical cord blood mononuclear stem cells.International journal of clinical and experimental pathology · 2011Article
- Immune Reactions following Cord Blood Transplantations in Adults.Stem cells international · 2011Article
- Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues.Journal of the Royal Society, Interface · 2010Review
- Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host?Blood · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent registry studies have established umbilical cord blood (UCB) transplantation as a safe and feasible alternative to bone marrow transplantation in adults when no sibling donor is available. There is, however, no gold standard to guide optimal treatment choices. We review here factors leading to the choice of the 'best available donor' and 'best available unit' in the case of UCB. For instance, it is clear that higher cell dose may partially overcome the negative impact of certain histocompatibility leukocyte antigen (HLA) disparities in UCB transplantation, leading us to choose the more closely HLA-matched unit with a cell dose >2.5 x 10(7)/kg. New approaches in adult UCB transplantation are systematically covered, with a quantitative appreciation of the evidence available to date. Reduced intensity conditioning, for example, broadens the range of potential recipients by reducing transplant-related mortality, but suffers from unproven risks and benefits long term. Potential advantages of multiple units over single unit transplants are discussed, with a particular emphasis on confounding factors that impact interpretation. The limited clinical results of ex vivo UCB expansion, the possible benefits of co-infusion of haploidentical cells and controversial issues (e.g. killer immunoglobulin-like receptor matching and alternative graft sources) are also addressed with a debate on the future of UCB transplantation.
Indexed as
Identifiers
16751788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.