ArticleGenetics2006
A nonself recognition gene complex in Neurospora crassa.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Vegetative incompatibility loci with dedicated roles in allorecognition restrict mycovirus transmission in chestnut blight fungus.Genetics · 2014Article
- Natural variation of heterokaryon incompatibility gene het-c in Podospora anserina reveals diversifying selection.Molecular biology and evolution · 2014Article
- Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in neurospora.Genetics · 2013Article
- Trans-species activity of a nonself recognition domain.BMC microbiology · 2013Article
- Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa.Genetics · 2012Article
- Article
- Sex and speciation: the paradox that non-recombining DNA promotes recombination.Fungal biology reviews · 2011Article
- Article
- Development of a conditional gene expression system using a zearalenone-inducible promoter for the ascomycete fungus Gibberella zeae.Applied and environmental microbiology · 2010Article
- De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis.PLoS genetics · 2010Article
- Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation?Annual review of ecology, evolution, and systematics · 2008Article
- Dominant suppression of repeat-induced point mutation in Neurospora crassa by a variant catalytic subunit of DNA polymerase zeta.Genetics · 2008Article
- The fungus-specific HET domain mediates programmed cell death in Podospora anserina.Eukaryotic cell · 2007Article
- Recurrent locus-specific mutation resulting from a cryptic ectopic insertion in Neurospora.Genetics · 2007Article
- VIB-1 is required for expression of genes necessary for programmed cell death in Neurospora crassa.Eukaryotic cell · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonself recognition is exemplified in the fungal kingdom by the regulation of cell fusion events between genetically different individuals (heterokaryosis). The het-6 locus is one of approximately 10 loci that control heterokaryon incompatibility during vegetative growth of N. crassa. Previously, it was found that het-6-associated incompatibility in Oak Ridge (OR) strains involves two contiguous genes, het-6 and un-24. The OR allele of either gene causes "strong" incompatibility (cell death) when transformed into Panama (PA)-background strains. Several remarkable features of the locus include the nature of these incompatibility genes (het-6 is a member of a repetitive gene family and un-24 also encodes the large subunit of ribonucleotide reductase) and the observation that un-24 and het-6 are in severe linkage disequilibrium. Here, we identify "weak" (slow, aberrant growth) incompatibility activities by un-24PA and het-6PA when transformed separately into OR strains, whereas together they exhibit an additive, strong effect. We synthesized strains with the new allelic combinations un-24PA het-6OR and un-24OR het-6PA, which are not found in nature. These strains grow normally and have distinct nonself recognition capabilities but may have reduced fitness. Comparing the Oak Ridge and Panama het-6 regions revealed a paracentric inversion, the architecture of which provides insights into the evolution of the un-24-het-6 gene complex.
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