ArticleApplied and environmental microbiology2006
A mutation in Flavobacterium psychrophilum tlpB inhibits gliding motility and induces biofilm formation.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Genetic and phenotypic diversity of Flavobacterium psychrophilum isolates from Czech salmonid fish farms.BMC microbiology · 2024Article
- Parallel evolution of alternate morphotypes of Chryseobacterium gleum during experimental evolution with Caenorhabditis elegans.FEMS microbiology ecology · 2024Article
- Biofouling inhibition by Staphylococcus aureus extracts and their potential use for paints.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Transposon mutagenesis and genome sequencing identify two novel, tandem genes involved in the colony spreading ofFrontiers in cellular and infection microbiology · 2023Article
- Deciphering the Molecular Basis for Attenuation ofVaccines · 2021Article
- Comparative Genomic Analyses ofMicroorganisms · 2021Article
- Identification of genetic determinants of hemolytic activity of Riemerella anatipestifer using random transposon mutagenesis.Veterinary research · 2021Article
- Comparative genomics of Flavobacterium columnare unveils novel insights in virulence and antimicrobial resistance mechanisms.Veterinary research · 2021Article
- Secretion Systems in Gram-Negative Bacterial Fish Pathogens.Frontiers in microbiology · 2021Review
- The Type IX Secretion System Is Required for Virulence of the Fish Pathogen Flavobacterium psychrophilum.Applied and environmental microbiology · 2020Article
- A Disulfide Oxidoreductase (CHU_1165) Is Essential for Cellulose Degradation by Affecting Outer Membrane Proteins in Cytophaga hutchinsonii.Applied and environmental microbiology · 2020Article
- Riemerella anatipestifer GldM is required for bacterial gliding motility, protein secretion, and virulence.Veterinary research · 2019Article
- The Riemerella anatipestifer M949_RS01035 gene is involved in bacterial lipopolysaccharide biosynthesis.Veterinary research · 2018Article
- Stress Tolerance-Related Genetic Traits of Fish PathogenFrontiers in microbiology · 2018Article
- Gliding Motility and Expression of Motility-Related Genes in Spreading and Non-spreading Colonies ofFrontiers in microbiology · 2018Article
- Complete Genome Sequence ofGenome announcements · 2017Article
- Disruption of the M949_RS01915 gene changed the bacterial lipopolysaccharide pattern, pathogenicity and gene expression of Riemerella anatipestifer.Veterinary research · 2017Article
- Different Phenotypes of Mature Biofilm inFrontiers in cellular and infection microbiology · 2017Article
- More Than Gliding: Involvement of GldD and GldG in the Virulence ofFrontiers in microbiology · 2017Article
- The Emerging Fish PathogenFrontiers in microbiology · 2017Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Flavobacterium psychrophilum is a psychrotrophic, fish-pathogenic bacterium belonging to the Cytophaga-Flavobacterium-Bacteroides group. Tn4351-induced mutants deficient in gliding motility, growth on iron-depleted media, and extracellular proteolytic activity were isolated. Some of these mutants were affected in only one of these characteristics, whereas others had defects in two or more. FP523, a mutant deficient in all of these properties, was studied further. FP523 had a Tn4351 insertion in tlpB (thiol oxidoreductase-like protein gene), which encodes a 41.4-kDa protein whose sequence does not exhibit high levels of similar to the sequences of proteins having known functions. TlpB has two domains; the N-terminal domains has five transmembrane regions, whereas the C-terminal domains has the Cys-X-X-Cys motif and other conserved motifs characteristic of thiol:disulfide oxidoreductases. Quantitative analysis of the thiol groups of periplasmic proteins revealed that TlpB is required for reduction of these groups. The tlpB gene is part of the fpt (F. psychrophilum thiol oxidoreductase) operon that contains two other genes, tlpA and tpiA, which encode a thiol:disulfide oxidoreductase and a triosephosphate isomerase, respectively. FP523 exhibited enhanced biofilm formation and decreased virulence and cytotoxicity. Complementation with the tlpB loci restored the wild-type phenotype. Gliding motility and biofilm formation appear to be antagonistic properties, which are both affected by TlpB.
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