ArticleBiophysical journal2006
The role of flexible tethers in multiple ligand-receptor bond formation between curved surfaces.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
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- Protein Proximity Observed Using Fluorogen Activating Protein and Dye Activated by Proximal Anchoring (FAP-DAPA) System.ACS chemical biology · 2020Article
- Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation.ACS nano · 2018Article
- Article
- Binding equilibrium and kinetics of membrane-anchored receptors and ligands in cell adhesion: Insights from computational model systems and theory.Cell adhesion & migration · 2016Review
- Nanomechanical properties of protein-DNA layers with different oligonucleotide tethers.RSC advances · 2016Article
- Modeling Nanoparticle Targeting to a Vascular Surface in Shear Flow Through Diffusive Particle Dynamics.Nanoscale research letters · 2015Article
- Receptor-mediated membrane adhesion of lipid-polymer hybrid (LPH) nanoparticles studied by dissipative particle dynamics simulations.Nanoscale · 2015Article
- Sticky surface: sphere-sphere adhesion dynamics.Journal of biological dynamics · 2015Article
- Yielding elastic tethers stabilize robust cell adhesion.PLoS computational biology · 2014Article
- Margination of micro- and nano-particles in blood flow and its effect on drug delivery.Scientific reports · 2014Article
- Impact of flow on ligand-mediated bacterial flocculation.Mathematical biosciences · 2013Article
- From phage display to nanoparticle delivery: functionalizing liposomes with multivalent peptides improves targeting to a cancer biomarker.Bioconjugate chemistry · 2013Article
- Catechol Redox Induced Formation of Metal Core-Polymer Shell Nanoparticles.Chemistry of materials : a publication of the American Chemical Society · 2011Article
- Kinetics of nanoparticle targeting by dissipative particle dynamics simulations.Biomacromolecules · 2009Article
- Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells.Biorheology · 2009Article
- Optimization of functionalized polymer layers for specific targeting of mobile receptors on cell surfaces.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Impact of receptor-ligand distance on adhesion cluster stability.The European physical journal. E, Soft matter · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ligands mounted to surfaces via extensible tethers are present in nature and represent a growing class of molecules used to engineer adhesion in drug targeting, biosensing, self-assembling nanostructures, and in other biophysical research. Using a continuum approach with geometric and thermodynamic arguments, we derive a number of analytical expressions that relate key properties of single-tethered ligand-receptor interactions to multiple bond formation between curved surfaces. The theoretical predictions are in good agreement with measurements made with the surface forces apparatus. We establish that, when ligated, many tethers commonly used in biophysical research exhibit a discrete binding range that can be accurately measured with force spectroscopy. The distribution of bound ligated tethers is independent of the surfaces' interaction radius, R. The bridging force scales linearly with R, the tether's effective spring constant and grafting density, and with the ligand-receptor bond energy when the surfaces are in direct contact. These results are contrasted to bridging forces that evolve between plane-parallel geometries. Last, we show how our simple analytical reductions can be used to predict adhesive forces for STEALTH liposomes and other targeted and self-assembled nanoparticles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.