ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2006
Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Dissecting Complex and Multifactorial Nature of Alzheimer's Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective.Molecular neurobiology · 2016Pooled it
- Genetic variation in imprinted genes is associated with risk of late-onset Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2015Article
- Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Review
- Fine mapping of the chromosome 10q11-q21 linkage region in Alzheimer's disease cases and controls.Neurogenetics · 2010Article
- Epigenetic approaches to psychiatric disorders.Dialogues in clinical neuroscience · 2010Review
- Article
- Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease.Neurology · 2008Article
- A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.Neurogenetics · 2007Article
- Lack of association of two chromosome 10q24 SNPs with Alzheimer's disease.Neuroscience letters · 2006Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
The chromosome 10q region has recently received a great deal of attention in late-onset Alzheimer's disease (LOAD), given the growing evidence of linkage to LOAD, or to A-beta levels, reported by several groups. In a recent paper we reported evidence of linkage in this region in our subset of the NIMH AD genetics initiative pedigrees, approaching genome-wide significance (non-parametric LOD score = 3.27), when only families with maternal disease origin were analyzed [Bassett et al. (2002); Am J Med Genet 114:679-686]. We have now extended this work, using an independent subset of NIMH AD pedigrees from the University of Alabama at Birmingham (UAB), and show further evidence of linkage using parent-of-origin information. As in our Hopkins sample, maternal but not paternal pedigrees show significantly increased linkage in the chromosome 10q region compared to the unstratified sample. Combining data from our previous fine-mapping work on this region and five new markers genotyped in all pedigrees results in a non-parametric LOD score of 3.73 in the same region, a value that reaches genome wide significance for linkage, with an empirical P value = 0.003. These results support our earlier findings and narrow the region of interest. In combination with findings from other groups, these results provide further evidence that this chromosome 10 region harbors a gene implicated in LOAD, and our use of parent-of-origin information has been useful in further narrowing the region of interest.
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