ArticleThe Journal of infectious diseases2006
Differential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian influenza viruses.
Article in The Journal of infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 88 citations in OpenAlex.
- Neonatal outcomes after influenza immunization during pregnancy: a randomized controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2012Trial
- Avian Influenza H5N1 Infection During Pregnancy: Preparing for the Next Flu Pandemic and Improving Perinatal Outcomes.Viruses · 2026Review
- Pathogenesis Induced by Influenza Virus Infection: Role of the Early Events of the Infection and the Innate Immune Response.Viruses · 2025Review
- Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newborns.Frontiers in immunology · 2024Article
- Review
- Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza.Frontiers in immunology · 2022Article
- Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection.Nature immunology · 2021Article
- Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.Human molecular genetics · 2021Article
- The Role of Innate Leukocytes during Influenza Virus Infection.Journal of immunology research · 2019Review
- In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice.Virology journal · 2017Article
- Attenuation of the virulence of a recombinant influenza virus expressing the naturally truncated NS gene from an H3N8 equine influenza virus in mice.Veterinary research · 2016Article
- The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice.Influenza and other respiratory viruses · 2016Article
- Influenza A Viruses Replicate Productively in Mouse Mastocytoma Cells (P815) and Trigger Pro-inflammatory Cytokine and Chemokine Production through TLR3 Signaling Pathway.Frontiers in microbiology · 2016Article
- The mRNA and Proteins Expression Levels Analysis of TC-1 Cells Immune Response to H9N2 Avian Influenza Virus.Frontiers in microbiology · 2016Article
- Susceptibility of bone marrow-derived macrophages to influenza virus infection is dependent on macrophage phenotype.The Journal of general virology · 2015Article
- Innate immune sensing and response to influenza.Current topics in microbiology and immunology · 2015Article
- PI3K/Akt signaling pathway modulates influenza virus induced mouse alveolar macrophage polarization to M1/M2b.PloS one · 2014Article
- Influenza virus-induced lung inflammation was modulated by cigarette smoke exposure in mice.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1997, avian influenza virus H5N1 was transmitted directly from chicken to human and resulted in a severe disease that had a higher mortality rate in adults than in children. The characteristic mononuclear leukocyte infiltration in the lung and the high inflammatory response in H5N1 infection prompted us to compare the chemokine responses between influenza virus-infected adult and neonatal monocyte-derived macrophages (MDMs). The effects of avian influenza virus A/Hong Kong/483/97 (H5N1) (H5N1/97), its precursor A/Quail/Hong Kong/G1/97 (H9N2) (H9N2/G1), and human influenza virus A/Hong Kong/54/98 (H1N1) (H1N1/98) were compared. Significantly higher expression of CCL2, CCL3, CCL5, and CXCL10 was induced by avian influenza viruses than by human influenza virus. Moreover, the increase in CCL3 expression in H5N1/97-infected adult MDMs was significantly higher than that in neonatal MDMs. Enhanced expression of CCR1 and CCR5 was found in avian virus-infected adult MDMs. The strong induction of chemokines and their receptors by avian influenza viruses, particularly in adult MDMs, may account for the severity of H5N1 disease.
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