ArticleMolecular genetics and genomics : MGG2006
Transcriptome profiling of Saccharomyces cerevisiae during a transition from fermentative to glycerol-based respiratory growth reveals extensive metabolic and structural remodeling.
Article in Molecular genetics and genomics : MGG, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed.
- Advances in glycerol metabolism comprehension in yeasts: from regulation to metabolic engineering strategies.World journal of microbiology & biotechnology · 2026Review
- Metabolomic Profiling ofJournal of fungi (Basel, Switzerland) · 2026Article
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- Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry.Biotechnology for biofuels and bioproducts · 2024Review
- Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition.Nucleic acids research · 2024Article
- Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity inAntioxidants (Basel, Switzerland) · 2023Article
- The Lipid Profile of theJournal of fungi (Basel, Switzerland) · 2022Article
- Identification of the Aldo-Keto Reductase Responsible for d-Galacturonic Acid Conversion to l-Galactonate inJournal of fungi (Basel, Switzerland) · 2021Article
- Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae.Journal of cell science · 2021Article
- A Putative Bet-Hedging Strategy Buffers Budding Yeast against Environmental Instability.Current biology : CB · 2020Article
- Preventing Photomorbidity in Long-Term Multi-color Fluorescence Imaging ofG3 (Bethesda, Md.) · 2020Article
- Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.Cells · 2020Article
- Deciphering eukaryotic gene-regulatory logic with 100 million random promoters.Nature biotechnology · 2020Article
- EngineeringFrontiers in bioengineering and biotechnology · 2020Article
- Transcriptome Profile of Yeast Strain Used for Biological Wine Aging Revealed Dynamic Changes of Gene Expression in Course of Flor Development.Frontiers in microbiology · 2020Article
- A Cholesterol Analog Induces an Oligomeric Reorganization of VDAC.Biophysical journal · 2019Article
- Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae.Microbial cell factories · 2018Article
- The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally.Epigenetics & chromatin · 2018Article
- Regulation of Mammalian Mitochondrial Gene Expression: Recent Advances.Trends in biochemical sciences · 2017Review
2 more citing papers are in PubMed but not listed here.
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Abstract
Transcriptome analyses using a wild-type strain of Saccharomyces cerevisiae were performed to assess the overall pattern of gene expression during the transition from glucose-based fermentative to glycerol-based respiratory growth. These experiments revealed a complex suite of metabolic and structural changes associated with the adaptation process. Alterations in gene expression leading to remodeling of various membrane transport systems and the cortical actin cytoskeleton were observed. Transition to respiratory growth was accompanied by alterations in transcript patterns demonstrating not only a general stress response, as seen in earlier studies, but also the oxidative and osmotic stress responses. In some contrast to earlier studies, these experiments identified modulation of expression for many genes specifying transcription factors during the transition to glycerol-based growth. Importantly and unexpectedly, an ordered series of changes was seen in transcript levels from genes encoding components of the TFIID, SAGA (Spt-Ada-Gcn5-Acetyltransferase), and SLIK (Saga LIKe) complexes and all three RNA polymerases, suggesting a modulation of structure for the basal transcriptional machinery during adaptation to respiratory growth. In concert with data given in earlier studies, the results presented here highlight important aspects of metabolic and other adaptations to respiratory growth in yeast that are common to utilization of multiple carbon sources. Importantly, they also identify aspects specific to adaptation of this organism to growth on glycerol as sole carbon source.
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