SynthesisHuman genetics2006
Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.
Synthesis in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Gene- and evidence-based candidate gene selection for schizophrenia and gene feature analysis.Artificial intelligence in medicinePooled it
- A rare case of schizophrenia coexistence with antiphospholipid syndrome, β-thalassemia, and monoclonal gammopathy of undetermined significance.Frontiers in psychiatry · 2023Article
- Relationships of Ischemic Stroke Occurrence and Outcome with Gene Variants Encoding Enzymes of Tryptophan Metabolism.Biomedicines · 2021Article
- Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function.Neuromolecular medicine · 2020Article
- Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia.PloS one · 2018Article
- Evaluating the dopamine hypothesis of schizophrenia in a large-scale genome-wide association study.Schizophrenia research · 2016Article
- Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population.Neuropsychiatric disease and treatment · 2015Article
- 13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients.Translational psychiatry · 2012Article
- Tryptophan hydroxylase 2 gene and alcohol use among college students.Addiction biology · 2008Article
- Comments on the paper by D. Li and L. He: meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia.Human genetics · 2007Article
- Dopamine genes and schizophrenia: case closed or evidence pending?Schizophrenia bulletin · 2007Review
- Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.BMC psychiatry · 2007Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of studies have suggested an association between schizophrenia and the tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) genes. On the other hand, several studies attempting to replicate these findings have produced mixed results, possibly reflecting inadequate statistical power of the individual studies as well as the heterogeneity inherent in schizophrenia. In an attempt to clarify this inconsistency our meta-analysis has combined all the studies using multiple research methods published up to February 2006 to give a comprehensive picture of the role of three hydroxylase-related genes. The TPH A218C/A779C (OR = 1.18, 95% C.I. 1.06-1.33, P = 0.004) revealed a significant association with schizophrenia. However, the evidence for the TH and phenylalanine hydroxylase (PAH) genes was weak. No publication bias was detected in current studies. The findings, which may implicate the involvement of TPH in the pathogenesis of schizophrenia, have potentially important clinical, scientific and public health implications as well as providing a putative basis for the study of hydroxylase-related drugs. To our knowledge, this is the first meta-analysis of association between the three genes and schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.