ArticlePLoS computational biology2006
The G protein-coupled receptor subset of the chicken genome.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- 3D transparent technology displays the developmental patterns of ductus arteriosus morphology in chicken embryos before and after birth.Journal of anatomy · 2026Article
- Interaction of the Vagus Nerve and Serotonin in the Gut-Brain Axis.International journal of molecular sciences · 2025Review
- Genome-Wide Identification of G Protein-Coupled Receptors in Ciliated Eukaryotes.International journal of molecular sciences · 2023Article
- Effects of genotype, sex, and feed restriction on the biochemical composition of chicken preen gland secretions and their implications for commercial poultry production.Journal of animal science · 2023Article
- The avian taste system.Frontiers in physiology · 2023Review
- Genomic insight into the nocturnal adaptation of the black-crowned night heron (Nycticorax nycticorax).BMC genomics · 2022Article
- Uncovering the core principles of the gut-lung axis to enhance innate immunity in the chicken.Frontiers in immunology · 2022Article
- Connecting gut microbiomes and short chain fatty acids with the serotonergic system and behavior inFrontiers in physiology · 2022Review
- Effects of Diet and Phytogenic Inclusion on the Antioxidant Capacity of the Broiler Chicken Gut.Animals : an open access journal from MDPI · 2021Article
- ADGRL4/ELTD1 is a highly conserved angiogenesis-associated orphan adhesion GPCR that emerged with the first vertebrates and comprises 3 evolutionary variants.BMC evolutionary biology · 2019Article
- Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes.Scientific reports · 2019Article
- Contaminants in bald eagles of the upper Midwestern U.S.: A framework for prioritizing future research based on in-vitro bioassays.Environmental pollution (Barking, Essex : 1987) · 2019Article
- The role of GPCRs in bone diseases and dysfunctions.Bone research · 2019Review
- Regulation of CD4Scientific reports · 2018Article
- An Update on the Sense of Taste in Chickens: A Better Developed System than Previously Appreciated.Journal of nutrition & food sciences · 2018Article
- Molecular basis of fatty acid taste ineLife · 2017Article
- Distribution of α-Gustducin and Vimentin in premature and mature taste buds in chickens.Biochemical and biophysical research communications · 2016Article
- Contrasting Patterns of Evolutionary Diversification in the Olfactory Repertoires of Reptile and Bird Genomes.Genome biology and evolution · 2016Article
- Expanding Duplication of Free Fatty Acid Receptor-2 (GPR43) Genes in the Chicken Genome.Genome biology and evolution · 2015Article
- The Orphan G Protein-Coupled Receptor Gene GPR178 Is Evolutionary Conserved and Altered in Response to Acute Changes in Food Intake.PloS one · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G protein-coupled receptors (GPCRs) are one of the largest families of proteins, and here we scan the recently sequenced chicken genome for GPCRs. We use a homology-based approach, utilizing comparisons with all human GPCRs, to detect and verify chicken GPCRs from translated genomic alignments and Genscan predictions. We present 557 manually curated sequences for GPCRs from the chicken genome, of which 455 were previously not annotated. More than 60% of the chicken Genscan gene predictions with a human ortholog needed curation, which drastically changed the average percentage identity between the human-chicken orthologous pairs (from 56.3% to 72.9%). Of the non-olfactory chicken GPCRs, 79% had a one-to-one orthologous relationship to a human GPCR. The Frizzled, Secretin, and subgroups of the Rhodopsin families have high proportions of orthologous pairs, although the percentage of amino acid identity varies. Other groups show large differences, such as the Adhesion family and GPCRs that bind exogenous ligands. The chicken has only three bitter Taste 2 receptors, and it also lacks an ortholog to human TAS1R2 (one of three GPCRs in the human genome in the Taste 1 receptor family [TAS1R]), implying that the chicken's ability and mode of detecting both bitter and sweet taste may differ from the human's. The chicken genome contains at least 229 olfactory receptors, and the majority of these (218) originate from a chicken-specific expansion. To our knowledge, this dataset of chicken GPCRs is the largest curated dataset from a single gene family from a non-mammalian vertebrate. Both the updated human GPCR dataset, as well the chicken GPCR dataset, are available for download.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.