ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Purkinje cell loss by OX7-saporin impairs acquisition and extinction of eyeblink conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits.Alcohol (Fayetteville, N.Y.) · 2022Article
- Neural Substrates Underlying Eyeblink Classical Conditioning in Adults With Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2020Article
- Eyeblink Classical Conditioning in Alcoholism and Fetal Alcohol Spectrum Disorders.Frontiers in psychiatry · 2015Review
- Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats.Neurobiology of learning and memory · 2014Article
- Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.Human brain mapping · 2014Article
- Differential effects of the cannabinoid agonist WIN55,212-2 on delay and trace eyeblink conditioning.Behavioral neuroscience · 2013Article
- Cerebellar structure and function in male Wistar-Kyoto hyperactive rats.Behavioral neuroscience · 2013Article
- Article
- Evaluation of bidirectional interstimulus interval (ISI) shift in auditory delay eye-blink conditioning in healthy humans.Learning & behavior · 2011Article
- Retention and extinction of delay eyeblink conditioning are modulated by central cannabinoids.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Review
- Central cannabinoid receptors modulate acquisition of eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- MK-801 administration during neonatal ethanol withdrawal attenuates interpositus cell loss and juvenile eyeblink conditioning deficits.Alcohol (Fayetteville, N.Y.) · 2010Article
- The cerebellum harbors a circadian oscillator involved in food anticipation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Effects of extinction on classical conditioning and conditioning-specific reflex modification of rabbit heart rate.Behavioural brain research · 2010Article
- Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
- Eyeblink conditioning during an interstimulus interval switch in rabbits (Oryctolagus cuniculus) using picrotoxin to disrupt cerebellar cortical input to the interpositus nucleus.Behavioral neuroscience · 2009Article
- Neonatal binge alcohol exposure produces dose dependent deficits in interstimulus interval discrimination eyeblink conditioning in juvenile rats.Brain research · 2009Article
- Cross-modal transfer of the conditioned eyeblink response during interstimulus interval discrimination training in young rats.Developmental psychobiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The current study examined the effects of globally depleting Purkinje cells in the cerebellar cortex with the immunotoxin OX7-saporin on acquisition and extinction of delay eyeblink conditioning in rats. Rats were given OX7-saporin or saline 2 wk before the start of eyeblink conditioning. The rats that reached a performance criterion of two consecutive days with 80% or greater conditioned responses were given 5 d of extinction training followed by 2 d of reacquisition training. Rats that received infusions of OX7-saporin had 77.2%-97.9% Purkinje cell loss and exhibited impaired acquisition and extinction. The amount of Purkinje cell loss was correlated with the magnitude of the acquisition and extinction impairments. The highest correlations between Purkinje cell number and the rate of acquisition were in lobule HVI and the anterior lobe. The highest negative correlation between Purkinje cell number and the percentage of conditioned responses during extinction was in the anterior lobe. The results indicate that cerebellar Purkinje cells, particularly in the anterior lobe and lobule HVI, play significant roles in acquisition and extinction of eyeblink conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.