ArticleJournal of bacteriology2006
DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Atomic Force Microscopy Investigation of the Interactions between the MCM Helicase and DNA.Materials (Basel, Switzerland) · 2021Article
- Characterization of the replication initiator Orc1/Cdc6 from the Archaeon Picrophilus torridus.Journal of bacteriology · 2014Article
- Mutational analysis of conserved aspartic acid residues in the Methanothermobacter thermautotrophicus MCM helicase.Extremophiles : life under extreme conditions · 2011Article
- Biochemical characterization of the minichromosome maintenance protein from the archaeon Thermoplasma acidophilum.Extremophiles : life under extreme conditions · 2009Article
- Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by regulating its ATPase activity.Nucleic acids research · 2008Article
- The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase.Journal of bacteriology · 2008Article
- Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.