ArticleJournal of bacteriology2006
Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 73 citations in OpenAlex.
- A Refined Developmental Transcriptomic Landscape Reveals Four Coordinated Programs inbioRxiv : the preprint server for biology · 2026Article
- Restriction and evasion: a review of IFNγ-mediated cell-autonomous defense pathways during genital Chlamydia infection.Pathogens and disease · 2024Review
- Article
- Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023Review
- Chlamydia trachomatis RsbU Phosphatase Activity Is Inhibited by the Enolase Product, Phosphoenolpyruvate.Journal of bacteriology · 2022Article
- The role of tryptophan inFrontiers in cellular and infection microbiology · 2022Review
- Article
- GrgA overexpression inhibits Chlamydia trachomatis growth through sigmaMicrobial pathogenesis · 2021Article
- Article
- The Koala Immune Response to Chlamydial Infection and Vaccine Development-Advancing Our Immunological Understanding.Animals : an open access journal from MDPI · 2021Review
- The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis.Nature communications · 2020Article
- The Repressor Function of theJournal of bacteriology · 2020Article
- Inhibition of tRNA Synthetases Induces Persistence inInfection and immunity · 2020Article
- Ammonia generation by tryptophan synthase drives a key genetic difference between genital and ocularProceedings of the National Academy of Sciences of the United States of America · 2019Article
- HowProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway ineLife · 2019Article
- Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in UniqueFrontiers in microbiology · 2019Article
- Inflammation, infection and depression: an evolutionary perspective.Evolutionary human sciences · 2019Article
- Metagenomic Analysis of Fish-Associated Ca. Parilichlamydiaceae Reveals Striking Metabolic Similarities to the Terrestrial Chlamydiaceae.Genome biology and evolution · 2018Article
- Characterization of theInfection and immunity · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tryptophan is an essential amino acid that is required for normal development in Chlamydia species, and tryptophan metabolism has been implicated in chlamydial persistence and tissue tropism. The ability to synthesize tryptophan is not universal among the Chlamydiaceae, but species that have a predicted tryptophan biosynthetic pathway also encode an ortholog of TrpR, a regulator of tryptophan metabolism in many gram-negative bacteria. We show that in Chlamydia trachomatis serovar D, TrpR regulates its own gene and trpB and trpA, the genes for the two subunits of tryptophan synthase. These three genes form an operon that is transcribed by the major form of chlamydial RNA polymerase. TrpR acts as a tryptophan-dependent aporepressor that binds specifically to operator sequences upstream of the trpRBA operon. We also found that TrpR repressed in vitro transcription of trpRBA in a promoter-specific manner, and the level of repression was dependent upon the concentrations of TrpR and tryptophan. Our findings provide a mechanism for chlamydiae to sense changes in tryptophan levels and to respond by modulating expression of the tryptophan biosynthesis genes, and we present a unified model that shows how C. trachomatis can combine transcriptional repression and attenuation to regulate intrachlamydial tryptophan levels. In the face of host defense mechanisms that limit tryptophan availability from the infected cell, the ability to maintain homeostatic control of intrachlamydial tryptophan levels is likely to play an important role in chlamydial pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.