ArticleJournal of medical genetics2006
A new locus for autosomal dominant intracranial aneurysm, ANIB4, maps to chromosome 5p15.2-14.3.
Article in Journal of medical genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of whole-genome linkage scans for intracranial aneurysm.Neuroscience letters · 2008Pooled it
- Intracranial Aneurysms and Genetics: An Extensive Overview of Genomic Variations, Underlying Molecular Dynamics, Inflammatory Indicators, and Forward-Looking Insights.Brain sciences · 2023Review
- Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.Neuromolecular medicine · 2019Review
- A Review of the Genetics of Intracranial Berry Aneurysms and Implications for Genetic Counseling.Journal of genetic counseling · 2017Review
- Molecular mechanisms of the formation and progression of intracranial aneurysms.Neurologia medico-chirurgica · 2015Review
- Molecular basis and genetic predisposition to intracranial aneurysm.Annals of medicine · 2014Review
- A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm.Journal of medical genetics · 2012Article
- Interactions of miR-34b/c and TP53 polymorphisms on the risk of intracranial aneurysm.Clinical & developmental immunology · 2012Article
- Autosomal dominant inheritance of a predisposition to thoracic aortic aneurysms and dissections and intracranial saccular aneurysms.American journal of medical genetics. Part A · 2011Article
- Genome screen in familial intracranial aneurysm.BMC medical genetics · 2009Article
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- Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23.Journal of human genetics · 2008Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial aneurysms (IA) are dilatations of intracranial arteries that occur most commonly at arterial bifurcations. Unruptured IA are present in approximately 1-2% of the population aged over 30 years of age. Aneurysms are only rarely symptomatic unless they rupture, which typically results in a subarachnoid haemorrhage associated with high morbidity and mortality.
methodsA large French Canadian (FC) family (Aneu60) was identified which contained 12 affected individuals with intracranial aneurysms. Nine of the affected patients and three unaffected individuals were sent for an 8 cM genome-wide scan. Multipoint and two-point methods were used to analyse the scan data by using a dominant parametric model.
resultsWe identified an IA susceptibility locus (ANIB4) located on chromosome 5p15.2-14.3. The locus was found by genome-wide linkage analysis and follow up analyses provided a maximum multipoint LOD score of 3.57 over the region. An identical haplotype segment of 7.2 Mb was found in a second FC pedigree and contributes to the refinement of the candidate gene interval.
conclusionsOur results indicate that there is a major gene locus on chromosome 5p.
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