ArticleJournal of neurology, neurosurgery, and psychiatry2006
Severe head injury and the risk of early death.
Article in Journal of neurology, neurosurgery, and psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Incidence and mortality related risk factors in patients with severe traumatic brain injury: A meta‑analysis.Experimental and therapeutic medicine · 2025Article
- Traumatic Brain Injury Guideline Implementation at a University Hospital in Saudi Arabia.Life (Basel, Switzerland) · 2025Article
- Review
- Review: Emerging Eye-Based Diagnostic Technologies for Traumatic Brain Injury.IEEE reviews in biomedical engineering · 2023Review
- Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.Neurocritical care · 2022Observational
- Coagulopathy and its effect on treatment and mortality in patients with traumatic intracranial hemorrhage.Acta neurochirurgica · 2021Article
- Emergency department management of traumatic brain injuries: A resource tiered review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2020Review
- Article
- Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine diphosphate receptor.The journal of trauma and acute care surgery · 2019Article
- Correlation between cerebral co-oximetry (rSO2) and outcomes in traumatic brain injury cases: A prospective, observational study.Medical journal, Armed Forces India · 2019Article
- Genetic Background Influences Acute Response to TBI in Kindling-Susceptible, Kindling-Resistant, and Outbred Rats.Frontiers in neurology · 2019Article
- Relationship of Coagulopathy and Platelet Dysfunction to Transfusion Needs After Traumatic Brain Injury.Neurocritical care · 2018Article
- Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study.Critical care (London, England) · 2017Observational
- Predictors of mortality in patients with isolated severe traumatic brain injury.Wiener klinische Wochenschrift · 2017Article
- Outcome and Predicting Factor Following Severe Traumatic Brain Injury: A Retrospective Cross-Sectional Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Article
- Traumatic brain injury associated coagulopathy.Neurocritical care · 2015Observational
- Motorcycle-Related Traumatic Brain Injuries: Helmet Use and Treatment Outcome.Neuroscience journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere head injury (SHI) is one of the most important health, social and economic problems in industrialised countries. Unfortunately, none of the neuroprotection trials for traumatic brain injury have shown efficacy. One of the reasons for this failure could be the inclusion of patients with high probability of early death. A population-based, retrospective study was conducted to develop a prognostic model for identification of these patients.
methodsBetween January 1987 and August 1999, a total of 895 patients (> or = 15 years of age) with non-missile SHI were studied, in whom a computed tomography scan was carried out within the first 6 h of injury. The association between early death (first 48 h after injury) and independent prognostic factors was determined by logistic regression analysis. A scoring system was also constructed.
resultsThe early-death rate was 20%. Independent predictors of early mortality after SHI were non-evacuated mass (odds ratio (OR) 65, 95% confidence interval (CI) 11 to 379), diffuse injury IV (OR 25, 95% CI 5 to 112), diffuse injury III (OR 8, 95% CI 3 to 22), flaccidity (OR 7, 95% CI 3 to 15), non-reactive bilaterally mydriasis (OR 6, 95% CI 3 to 12), evacuated mass (OR 4, 95% CI 1 to 11), age > or = 65 years (OR 4, 95% CI 1 to 9), decerebration (OR 3, 95% CI 2 to 7) and shock (OR 3, 95% CI 2 to 6). The prognostic model correctly identified 93% of the patients.
conclusionsThis prognostic model is based on simple clinical and radiological data readily available during the first 6 h after injury and is useful for identification of early death after SHI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.