ReviewSpringer seminars in immunopathology2006
Disturbances in placental immunology: ready for therapeutic interventions?
Review in Springer seminars in immunopathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Importance of STAT3 signaling in preeclampsia (Review).International journal of molecular medicine · 2025Review
- Epigenetic role of LINE-1 methylation and key genes in pregnancy maintenance.Scientific reports · 2024Article
- Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal-Maternal Interface.Frontiers in oncology · 2020Review
- Janus-Faced Neutrophil Extracellular Traps in Periodontitis.Frontiers in immunology · 2017Review
- Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Genomic and proteomic investigation of preeclampsia.Experimental and therapeutic medicine · 2015Article
- Article
- Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss.Frontiers in immunology · 2012Article
- Biochemical markers for prediction of preclampsia: review of the literature.Journal of prenatal medicine · 2011Article
- Potential markers of preeclampsia--a review.Reproductive biology and endocrinology : RB&E · 2009Review
- Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage.Cell stress & chaperones · 2009Article
- Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.Seminars in immunopathology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have provided new insight into aberrations in the immunological interplay between mother and fetus and their potential role in the development of recurrent fetal loss and preeclampsia. The action of anti-phospholipid antibodies in recurrent fetal loss is now proposed to involve the complement system, neutrophil activation and the production of TNFalpha by immune bystander cells. A clear involvement of the immune system is emerging in preeclampsia, involving mainly the innate arm, especially neutrophils. The activation of peripheral neutrophils by placentally released inflammatory debris triggers the induction of neutrophil extracellular traps (NETs), which may lead to an occlusion of the intervillous space, thereby further promoting a condition of placental hypoxia. It has, hence, been suggested that new therapeutic strategies be developed, including the possible use of TNFalpha antagonists in cases of recurrent miscarriage. These strategies need to be addressed with caution due to the possible induction of fetal congenital abnormalities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.