ReviewSpringer seminars in immunopathology2006
Biological therapies directed against cells in autoimmune disease.
Review in Springer seminars in immunopathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Are biological agents toxic to human chondrocytes and osteocytes?Journal of orthopaedic surgery and research · 2015Article
- T cell recognition of naturally presented epitopes of self-heat shock protein 70.Cell stress & chaperones · 2014Article
- αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells.Investigative ophthalmology & visual science · 2012Article
- Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis.Autoimmunity · 2011Article
- Protective versus pathogenic anti-CD4 immunity: insights from the study of natural resistance to HIV infection.Journal of translational medicine · 2009Review
- Protective role of gammadelta T cells in spontaneous ocular inflammation.Investigative ophthalmology & visual science · 2009Article
- Parameters influencing antigen-specific immunotherapy for Type 1 diabetes.Immunologic research · 2008Article
- Parameters influencing antigen-specific immunotherapy for type 1 diabetes.Immunologic research · 2008Article
- Nanosystems for simultaneous imaging and drug delivery to T cells.The AAPS journal · 2007Review
- The use of Trichuris suis and other helminth therapies to treat Crohn's disease.Parasitology research · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the cells of the immune system involved in the pathogenesis of autoimmune disease, T cells have received the most attention. The central role of these cells in several animal models of autoimmune diseases and in human disease counterparts has provided the rationale for specific therapeutic targeting of T cell subsets, especially CD4 T cells. So far, the applicability of this approach has not been clearly evident in clinical trials, which was also the case when nondepleting "coating" anti-CD4 monoclonal antibodies was used. In the past several years, experimental evidence supporting a major role of B cells in systemic autoimmune disease has grown. This includes the pathogenicity of certain autoantibodies, the potential of B cells to present antigen in the context of MHC Class II and to signal via costimulatory molecules, and to secrete proinflammatory cytokines. In some instances, engagement of the B cell receptor and other surface receptors is sufficient to stimulate B cells to produce antibodies. The depletion of B cells by targeting the surface marker CD20 has been shown to be effective in treating rheumatoid arthritis with a good side effect profile. Series of cases with other systemic autoimmune diseases indicate that this strategy may be effective in these conditions too. The clinical data add weight to the importance of B cells in the pathogenesis of autoimmune diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.