ArticleRheumatology international2006
Interleukin-6 levels in synovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovial membrane.
Article in Rheumatology international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with rheumatoid arthritis.Arthritis research & therapy · 2018Trial
- Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial.Annals of the rheumatic diseases · 2017Trial
- Sarilumab and Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis and Inadequate Response or Intolerance to Tumor Necrosis Factor Inhibitors.Arthritis & rheumatology (Hoboken, N.J.) · 2017Trial
- Interleukin 6 Concentration in Synovial Fluid of Patients with Inflammatory and Degenerative Arthritis.Current rheumatology reviews · 2022Article
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects.PloS one · 2019Article
- Krüppel-Like Factor 4 Is a Regulator of Proinflammatory Signaling in Fibroblast-Like Synoviocytes through Increased IL-6 Expression.Mediators of inflammation · 2016Article
- Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis.Arthritis · 2012Article
- Cadherin-11 regulates fibroblast inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Recent advances in neutralizing the IL-6 pathway in arthritis.Open access rheumatology : research and reviews · 2009Review
- Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid.Rheumatology international · 2008Article
- High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life.Arthritis research & therapy · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To compare the histological appearance of synovial membrane and interleukin (IL)-6 levels in synovial fluids of patients with rheumatoid arthritis (RA). Synovial tissue and synovial fluids were obtained from 51 knee joints with RA undergoing synovectomy or joint replacements. A histological inflammation score was determined based on the hyperplasia of the synovial lining and infiltration of inflammatory cells. The concentrations of IL-6 in synovial fluids were measured by ELISA. The association between IL-6 levels and histological findings was evaluated. We found a positive correlation between the infiltration of inflammation cells in synovial tissues and the concentration of IL-6 in synovial fluids. The IL-6 level in synovial fluid partially reflects histological synovial inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.