ArticleMolecular systems biology2006
Noise resistance in the spindle assembly checkpoint.
Article in Molecular systems biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Unveiling inter-embryo variability in spindle length over time: Towards quantitative phenotype analysis.PLoS computational biology · 2024Article
- Types of potentials in a mitotic spindle.Biochemistry and biophysics reports · 2021Article
- Homeorhesis and ecological succession quantified in synthetic microbial ecosystems.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Determinants of robustness in spindle assembly checkpoint signalling.Nature cell biology · 2013Article
- Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module.PLoS computational biology · 2013Article
- Interplay between intrinsic noise and the stochasticity of the cell cycle in bacterial colonies.Biophysical journal · 2010Article
- A quantitative systems view of the spindle assembly checkpoint.The EMBO journal · 2009Review
- Reverse engineering of the spindle assembly checkpoint.PloS one · 2009Article
- Kinetochore structure and spindle assembly checkpoint signaling in the budding yeast, Saccharomyces cerevisiae.Frontiers in bioscience : a journal and virtual library · 2008Review
- Noise propagation and signaling sensitivity in biological networks: a role for positive feedback.PLoS computational biology · 2008Article
- Stable stochastic dynamics in yeast cell cycle.Biophysical journal · 2007Article
- Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.Genes & development · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetically identical cells vary in the amount of expressed proteins even when growing under the same conditions. It is not yet clear how cellular information processing copes with such stochastic fluctuations in protein levels. Here we examine the capacity of the spindle assembly checkpoint to buffer temporal fluctuations in the expression of Cdc20, a critical checkpoint target whose activity is inhibited to prevent premature cell cycle progression. Using mathematical modeling, we demonstrate that the checkpoint can buffer significant fluctuations in Cdc20 production rate. Critical to this buffering capacity is the use of sequestering-based mechanism for inhibiting Cdc20, as apposed to inhibition by enhancing protein degradation. We propose that the design of biological networks is limited by the need to overcome noise in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.