ArticleMolecular systems biology2006
Proteome analysis of yeast response to various nutrient limitations.
Article in Molecular systems biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 153 citations in OpenAlex.
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- The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition.The EMBO journal · 2023Article
- Comprehensive Response ofMicroorganisms · 2023Article
- Microbe-loaded bioink designed to support therapeutic yeast growth.Biomaterials science · 2023Article
- A tractable physical model for the yeast polarity predicts epistasis and fitness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- A Review of the Bacterial Phosphoproteomes of Beneficial Microbes.Microorganisms · 2023Review
- Are Marine Heatwaves Responsible for Mortalities of FarmedAnimals : an open access journal from MDPI · 2022Article
- Proteome changes in an aquatic invertebrate consumer in response to different nutritional stressors.Oecologia · 2022Article
- Protein complexes and neighborhoods driving autophagy.Autophagy · 2021Review
- Energy metabolism controls phenotypes by protein efficiency and allocation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.Membranes · 2014Review
- Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal.The Journal of biological chemistry · 2014Article
- An evolutionarily conserved RNase-based mechanism for repression of transcriptional positive autoregulation.Molecular microbiology · 2014Article
- Glucose induces rapid changes in the secretome of Saccharomyces cerevisiae.Proteome science · 2014Article
- Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation.Molecular & cellular proteomics : MCP · 2013Article
- Protein analysis by shotgun/bottom-up proteomics.Chemical reviews · 2013Review
- Transimulation - protein biosynthesis web service.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared the response of Saccharomyces cerevisiae to carbon (glucose) and nitrogen (ammonia) limitation in chemostat cultivation at the proteome level. Protein levels were differentially quantified using unlabeled and 15N metabolically labeled yeast cultures. A total of 928 proteins covering a wide range of isoelectric points, molecular weights and subcellular localizations were identified. Stringent statistical analysis identified 51 proteins upregulated in response to glucose limitation and 51 upregulated in response to ammonia limitation. Under glucose limitation, typical glucose-repressed genes encoding proteins involved in alternative carbon source utilization, fatty acids beta-oxidation and oxidative phosphorylation displayed an increased protein level. Proteins upregulated in response to nitrogen limitation were mostly involved in scavenging of alternative nitrogen sources and protein degradation. Comparison of transcript and protein levels clearly showed that upregulation in response to glucose limitation was mainly transcriptionally controlled, whereas upregulation in response to nitrogen limitation was essentially controlled at the post-transcriptional level by increased translational efficiency and/or decreased protein degradation. These observations underline the need for multilevel analysis in yeast systems biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.