ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 103 citations in OpenAlex.
- Distribution and functional significance of KLF15 in mouse cerebellum.Molecular brain · 2025Article
- Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling.Neurochemical research · 2025Article
- The complex molecular epileptogenesis landscape of glioblastoma.Cell reports. Medicine · 2024Article
- Step by step: cells with multiple functions in cortical circuit assembly.Nature reviews. Neuroscience · 2022Review
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- Classics never get old: neurotransmitters shape human cortical interneuron migration.The EMBO journal · 2021Article
- Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration.The EMBO journal · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain.Frontiers in molecular neuroscience · 2021Article
- Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- AMPA receptor deletion in developing MGE-derived hippocampal interneurons causes a redistribution of excitatory synapses and attenuates postnatal network oscillatory activity.Scientific reports · 2020Article
- Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain.Frontiers in molecular neuroscience · 2020Article
- The Role of AMPARs in the Maturation and Integration of Caudal Ganglionic Eminence-Derived Interneurons into Developing Hippocampal Microcircuits.Scientific reports · 2019Article
- Perampanel in lissencephaly-associated epilepsy.Epilepsy & behavior case reports · 2019Article
- Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish.Molecular neurobiology · 2018Article
- NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum.PLoS biology · 2018Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons.eLife · 2016Article
- Neuronal activity controls the development of interneurons in the somatosensory cortex.Frontiers in biology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracrine GABA and glutamate acting, respectively, on GABAA and NMDA receptors modulate the migration of hippocampal pyramidal cells. Using corticohippocampal organotypic explants from glutamic acid decarboxylase (GAD) 67-enhanced green fluorescent protein (EGFP) knock-in embryos, we now report that, in contrast to pyramidal neurons, the blockade of AMPA but not NMDA receptors exerts important actions on the migration of GABAergic interneurons. In addition, the blockade of GABAA receptors fails to modify the migration rates of GABAergic interneurons. Immunohistochemical analyses of GAD67-EGFP embryos (from embryonic day 14 to birth) reveal that interneurons colonize the hippocampal primordium by embryonic day 15. At that stage, the hippocampal primordium is already composed of pioneer glutamatergic neurons, including (1) Cajal-Retzius cells, immunopositive to calretinin and reelin, and (2) other presumptive pioneer pyramidal cells that are immunopositive to betaIII-tubulin and vesicular glutamate transporter 3 and immunonegative to GABA or GAD67. Therefore, the migrations of pyramidal neurons and GABAergic interneurons are cross-modulated: glutamate released from pioneer glutamatergic neurons facilitates the migration of GABAergic interneurons, which in turn would release GABA, facilitating the migration of glutamatergic neuroblasts. This general sequence may provide a retroactive positive loop needed to construct the hippocampal network. It might constitute a primitive homeostatic mechanism in the developing brain that acts to balance GABA-glutamate contributions to network construction and activity.
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