Evidence map›Paper›PMID 16737824›Full record

ReviewSeminars in immunology2006

Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.

Lu Deng, Roy A Mariuzza

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Natural killer cells in multiple sclerosis: foe or friends?Frontiers in cellular neuroscience · 2025
    Review
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  11. Effects of MHC class I alleles on licensing of Ly49A+ NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2010
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lu DengCenter for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA. dorite@umbi.umd.edu
Roy A Mariuzza

Funding

STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORSR01AI047990 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI MARIUZZA, ROY A · 2000 to 2014
$4.1M
NIAID NIH HHS AI47990NIAID NIH HHS R01 AI047990
6 · The paper itself

Abstract

Natural killer (NK) cell function is regulated by NK cell receptors that bind classical MHC class I molecules or their structural relatives. The latter group includes self-ligands (MICA, RAE-I, H-60), as well as ligands encoded by viruses (UL18, m155, m157). Two distinct families of NK receptors have been identified: the immunoglobulin-like family (KIRs, LIRs) and the C-type lectin-like family (Ly49s, NKG2D, CD94/NKG2). Here we describe the crystal structures of NK receptors that have been determined to date, both in free form and bound to MHC class I or MHC class I-like molecules.

Indexed as

AnimalsHistocompatibility Antigens Class IHumansKiller Cells, NaturalLigandsMiceModels, MolecularReceptors, ImmunologicHistocompatibility Antigens Class ILigandsReceptors, Immunologic

Identifiers

PMID16737824
PMCPMC2519613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.