ReviewSeminars in immunology2006
The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions.
Review in Seminars in immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Targeting the NKG2D axis in head and neck squamous cell carcinoma: from molecular insights to clinical applications.Cancer cell international · 2026Review
- A promising natural killer cell-based model and a nomogram for the prognostic prediction of clear-cell renal cell carcinoma.European journal of medical research · 2024Article
- Article
- NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy.Biomaterials research · 2023Article
- β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression inFrontiers in immunology · 2023Article
- Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation.Cell reports · 2021Article
- Implications of a 'Third Signal' in NK Cells.Cells · 2021Review
- IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection.Scientific reports · 2019Article
- Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Natural Killer Cells: Development, Maturation, and Clinical Utilization.Frontiers in immunology · 2018Review
- Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy.Frontiers in immunology · 2016Review
- Evasion of natural killer cells by influenza virus.Journal of leukocyte biology · 2011Review
- Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion.Nucleic acids research · 2009Article
- Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.Current pharmaceutical design · 2008Review
- Regulation of ligands for the activating receptor NKG2D.Immunology · 2007Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
NK cells use NKG2D receptor to recognize 'induced-self'. In apparent violation of the 'missing-self' hypothesis, NK cells stimulated through NKG2D can lyse target cells despite normal expression levels of MHC class I molecules. Although, 'overriding' of the inhibitory by the activating signals had been postulated the precise role of inhibitory Ly49 receptors on NKG2D-mediated activation has only started emerging. We propose that NKG2D-mediated activation is a function of 'altering the balance' in the signaling strength between the activating NKG2D and inhibiting Ly49 receptors. Balance in the signaling strength depends on the expression levels of activating ligands on the target cells. Qualitative and quantitative variations of MHC class I molecules expressed on the target cells also plays a major role in determining this 'altered-balance'. Consequently, the nature of Ly49 receptors expressed on specific NK subsets determines the level of NKG2D-mediated NK cell activation. These observations provide a firm basis of 'altered-balance' in NK signaling and describe an active interplay between inhibitory Ly49 and activating NKG2D receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.