ArticleThe Journal of comparative neurology2006
Chemotopic representations of aromatic odorants in the rat olfactory bulb.
Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- The method for assessment of local permutations in the glomerular patterns of the rat olfactory bulb by aligning interindividual odor maps.Journal of computational neuroscience · 2023Article
- Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice.Molecules (Basel, Switzerland) · 2020Article
- Article
- Uncoupling stimulus specificity and glomerular position in the mouse olfactory system.Molecular and cellular neurosciences · 2012Article
- Glomerular activity patterns evoked by natural odor objects in the rat olfactory bulb are related to patterns evoked by major odorant components.The Journal of comparative neurology · 2010Article
- Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.The Journal of comparative neurology · 2009Article
- Olfactory detectability of homologous n-alkylbenzenes as reflected by concentration-detection functions in humans.Neuroscience · 2009Article
- Bulbar acetylcholine enhances neural and perceptual odor discrimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Learning-dependent structural plasticity in the adult olfactory pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Chemotopic odorant coding in a mammalian olfactory system.The Journal of comparative neurology · 2007Review
- Odorants with multiple oxygen-containing functional groups and other odorants with high water solubility preferentially activate posterior olfactory bulb glomeruli.The Journal of comparative neurology · 2007Article
- Effects of double and triple bonds on the spatial representations of odorants in the rat olfactory bulb.The Journal of comparative neurology · 2007Article
- Predicting odorant quality perceptions from multidimensional scaling of olfactory bulb glomerular activity patterns.Behavioral neuroscience · 2006Article
- Differential specificity in the glomerular response profiles for alicyclic, bicyclic, and heterocyclic odorants.The Journal of comparative neurology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Our laboratory has characterized spatial patterns of evoked neural activity across the entire glomerular layer of the rat olfactory bulb using primarily aliphatic odorants that differ systematically in functional groups and hydrocarbon structures. To represent more fully the true range of odorant chemistry, we investigated aromatic compounds, which have a more rigid molecular structure than most aliphatic compounds and are particularly salient olfactory stimuli for humans. We first investigated glomerular patterns of 2-deoxyglucose uptake in response to aromatic compounds that differ in the nature and position of their functional groups (e.g., xylenes, trimethylbenzenes, tolualdehydes, benzaldehydes, methyl toluates, and anisaldehydes). We also studied the effects of systematic increases in the number and length of alkyl substituents. We found that most aromatic compounds activated glomeruli in the dorsal part of the bulb. Within this general area, aromatic odorants with oxygen-containing substituents favored activation of more rostral regions, and aromatic hydrocarbons activated more posterior regions. The nature of substituents greatly affected the pattern of glomerular activation, whereas isomers differing in substitution position evoked very similar overall patterns. These relationships between the structure of aromatic compounds and their spatial representation in the bulb are contrasted with our previous findings with aliphatic odorants.
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