ReviewFamilial cancer2006
Interleukin-10 polymorphisms, cancer susceptibility and prognosis.
Review in Familial cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Functional polymorphisms in the IL-10 gene with susceptibility to esophageal, nasopharyngeal, and oral cancers.Cancer biomarkers : section A of Disease markers · 2016Pooled it
- Association of Interleukin-10 -3575T>A and -1082A>G polymorphisms with non-Hodgkin lymphoma susceptibility: a comprehensive review and meta-analysis.Molecular genetics and genomics : MGG · 2015Pooled it
- The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.Familial cancer · 2012Pooled it
- IL-10 polymorphisms and prostate cancer risk: a meta-analysis.Prostate cancer and prostatic diseases · 2011Pooled it
- IL-10 Polymorphism and Breast Cancer Risk in Georgian Women: A Case-Control Study.Global medical genetics · 2023Article
- Cytokines, Proliferation Markers, Antimicrobial Factors and Neuropeptide-Containing Innervation in Human Nasal Mucosa after Rhinoseptoplasty Procedure.Medical sciences (Basel, Switzerland) · 2021Article
- Association Between the Interleukin-17 Gene Polymorphism -197G>A and the Risk of Prostate Cancer in a Galician Population.Pathology oncology research : POR · 2020Article
- Racial Differences in Immunological Landscape Modifiers Contributing to Disparity in Prostate Cancer.Cancers · 2019Review
- Interleukin-10 (1082G/A) Polymorphism is Associated with Susceptibility of Acute Myeloid Leukemia Patients in Sudanese Population.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Association of IL10 gene promoter polymorphisms with risks of gastric cancer and atrophic gastritis.The Journal of international medical research · 2018Article
- Association of SNPs/haplotypes in promoter of TNF A and IL-10 gene together with life style factors in prostate cancer progression in Indian population.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017Article
- Association of serum cytokines with colorectal polyp number and type in adult males.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2016Article
- Significant roles played by interleukin-10 in outcome of pregnancy.Iranian journal of basic medical sciences · 2016Review
- Article
- A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women.Iranian journal of cancer prevention · 2015Article
- Characterization and Clinical Implication of Th1/Th2/Th17 Cytokines Produced from Three-Dimensionally Cultured Tumor Tissues Resected from Breast Cancer Patients.Translational oncology · 2015Article
- TGF-β1 and IL-10 single nucleotide polymorphisms as risk factors for oral cancer in Taiwanese.The Kaohsiung journal of medical sciences · 2015Article
- Little association between the interleukin 10-3575T/A polymorphism and cancer risk: pooled analysis of 15608 cancer cases and 17539 controls.International journal of clinical and experimental medicine · 2015Article
- Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms.Molecular and cellular biochemistry · 2014Article
- Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells.Cancer research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions and may have both tumour-promoting and -inhibiting properties. A large number of polymorphisms (primarily single nucleotide polymorphisms (SNPs)) have been identified in the IL-10 gene promoter. Convincing evidence that certain of these polymorphisms are associated with differential expression of IL-10 in vitro and in some cases in vivo has been obtained and a number of studies have investigated associations between IL-10 polymorphisms and cancer susceptibility/prognosis. The results from 22 studies in 13 different malignancies are reviewed. In 17 of these studies, positive associations between IL-10 genotype or haplotype and disease susceptibility and/or progression were reported. In some of these cancers genotypes associated with low IL-10 expression were a risk factor for disease or disease progression, while in others genotypes associated with high IL-10 expression were a risk factor. Published findings in breast cancer are as yet conflicting. Most, but not all of the studies reviewed are based on small sample sizes and a limited number of IL-10 polymorphisms. However, the preliminary data obtained thus far indicate that larger studies are required in a number of cancers, in order to confirm initial results, extend studies to include more detailed genotype/haplotype analysis and combine genotype and gene expression studies in the same subjects. Such studies will contribute significantly to our understanding of the biological role of IL-10 in cancer development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.