ArticleJournal of neural transmission (Vienna, Austria : 1996)2006
Association between a functional polymorphism in the renin-angiotensin system and completed suicide.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.Biochemical genetics · 2020Trial
- The potential role of brain renin-angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?Journal of cellular and molecular medicine · 2024Review
- Genome-wide association study of suicidal behaviour severity in mood disorders.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2021Article
- The renin-angiotensin system, mood, and suicide: Are there associations?World journal of psychiatry · 2021Review
- How Does COVID-19 Affect the Neurobiology of Suicide?Current psychiatry reports · 2021Review
- Hypertension Treatment Modality and Suicide Risk Among Veterans in Veterans Health Administration Care From 2015 to 2017.JAMA network open · 2020Article
- Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide.JAMA network open · 2019Article
- An overview of the neurobiology of suicidal behaviors as one meta-system.Molecular psychiatry · 2015Review
- The vascular depression hypothesis: mechanisms linking vascular disease with depression.Molecular psychiatry · 2013Review
- Renin angiotensin system gene polymorphisms modify angiotensin-converting enzyme inhibitors' effect on cognitive function: the health, aging and body composition study.Journal of the American Geriatrics Society · 2010Article
- Brain renin angiotensin in disease.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Stress, genes and the biology of suicidal behavior.The Psychiatric clinics of North America · 2008Review
- A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Clinical and genetic risk factors for suicide under the influence of alcohol in a Polish sample.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicide has been suggested to involve disturbances in the stress response system and to be related to genetics. The renin-angiotensin system (RAS) has been shown to affect the stress response, and several functional polymorphisms in RAS-related genes have been predicted to alter protein function. We hypothesized that the dysregulation of RAS was involved in suicide, and examined the association between completed suicides and four functional polymorphisms of RAS-related genes: the angiotensinogen M235T, angiotensin-converting enzyme (ACE) insertion(I)/deletion(D), angiotensin type-1 receptor A1166C, and G-protein-beta3 C825T gene polymorphisms. The I allele of the ACE I/D polymorphism was found to be more frequent in completed suicides than in controls (P = 0.014). The I allele was also found to be more frequent in male completed suicides (P = 0.022) than in male controls, while this was not the case in females. These results suggest that the alteration of RAS function caused by the genetic polymorphism is involved in the susceptibility to suicide in males.
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