ArticleThe Journal of general physiology2006
Statistical limits to the identification of ion channel domains by sequence similarity.
Article in The Journal of general physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels.bioRxiv : the preprint server for biology · 2025Article
- ClC Chloride Channels in Gram-Negative Bacteria and Its Role in the Acid Resistance Systems.Journal of microbiology and biotechnology · 2023Review
- Calcium-Activated KHandbook of experimental pharmacology · 2021Article
- Article
- Article
- BK channels: multiple sensors, one activation gate.Frontiers in physiology · 2015Review
- Interaction of the BKCa channel gating ring with dendrotoxins.Channels (Austin, Tex.) · 2014Article
- Transduction of voltage and Ca2+ signals by Slo1 BK channels.Physiology (Bethesda, Md.) · 2013Review
- The RCK1 domain of the human BKCa channel transduces Ca2+ binding into structural rearrangements.The Journal of general physiology · 2010Article
- Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy.Nature · 2009Article
- Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.Nature structural & molecular biology · 2008Article
- Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity.Molecular & cellular proteomics : MCP · 2008Article
- The RCK2 domain of the human BKCa channel is a calcium sensor.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Regulation of STREX exon large conductance, calcium-activated potassium channels by the beta4 accessory subunit.Neuroscience · 2007Article
- Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Gating rings formed by RCK domains: keys to gate opening.The Journal of general physiology · 2007Article
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Authors and funding
2 authors.
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Abstract
The study of ion channel function is constrained by the availability of structures for only a small number of channels. A commonly used bioinformatics technique is to assert, based on sequence similarity, that a domain within a channel of interest has the same structure as a reference domain for which the structure is known. This technique, while useful, is often employed when there is only a slight similarity between the channel of interest and the domain of known structure. In this study, we exploit recent advances in structural genomics to calculate the sequence-based probability of the presence of putative domains in a number of ion channels. We find strong support for the presence of many domains that have been proposed in the literature. For example, eukaryotic and prokaryotic CLC proteins almost certainly share a common structure. A number of proposed domains, however, are not as well supported. In particular, for the COOH terminus of the BK channel we find a number of literature proposed domains for which the assertion of common structure based on common sequence has a nontrivial probability of error.
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